Field Portable Instrument for Iodide Analysis

描述（由申请人提供）：碘缺乏症（IDD）已被世界卫生组织确定为严重的全球健康问题，影响130个国家的7.4亿人。缺碘是可预防的脑损伤的最常见原因，近5000万人患有某种程度的与缺碘有关的脑损伤。缺碘症可以通过食盐加碘来预防和治疗。要查明缺碘症患者和高危人群，就需要研制一种能够测量尿中碘化物和食盐中碘化物和碘酸盐的仪器。我们建议开发一种小型，轻便，廉价的仪器，快速碘分析仪（RIA），这将允许测量碘作为碘化物或碘酸盐。该仪器将基于一种新颖的专有检测方法，该方法在我们的第一阶段资助中得到了成功证明。它将是高度自动化的，将需要很少的样品制备。该便携式仪器预期具有<1 ppb的检测限，并且不受干扰。因此，灵敏度将足以诊断患有中度（20-49 ppb）或重度碘缺乏症（<20 ppb）的患者，以及尿中碘正常（100- 199 ppb）或过量（>300 ppb）的患者。由于其低成本（零售价<2，000美元）、便携性（<5磅）和低功率要求（<6瓦），RIA将非常适用于评估地球仪周围偏远地区人群的碘缺乏症，并用于检测这些地区分发的盐中是否存在碘添加剂。公共卫生相关性： 将研制一种高灵敏度（<1 ppb）便携式仪器，用于测量尿和食盐中的碘化物和碘酸盐。快速碘分析仪将是一个重要的新工具，用于解决目前影响130个国家7.4亿人的缺碘症问题。

DESCRIPTION (provided by applicant): Iodine deficiency disorder (IDD) has been identified by the World Health Organization as a serious global health problem affecting 740 million people in 130 countries. Iodine deficiency is the most common cause of preventable brain damage, with nearly 50 million people suffering some degree of IDD-related brain damage. IDD is preventable and treatable by iodization of table salt. Identification of individuals suffering from IDD and populations at risk requires the development of an instrument capable of measuring iodide in urine and both iodide and iodate in table salt. We propose to develop a small, lightweight, inexpensive instrument, the Rapid Iodine Analyzer (RIA), that will allow measurements of iodine present as either iodide or iodate. The instrument will be based on a novel and proprietary detection method successfully demonstrated in our Phase I grant. It will be highly automated and will require very little sample preparation. The portable instrument is expected to have a limit of detection of <1 ppb and to be free of interferences. Thus, the sensitivity will be adequate to diagnose patients as having moderate (20-49 ppb) or severe iodine deficiency (<20 ppb), as well as those having normal (100- 199 ppb) or excess iodine (>300 ppb) in their urine. Because of its low cost (<$2,000 retail), portability (<5 lb), and low power requirements (<6 watts), the RIA will be highly useful for assessing iodine deficiency in populations in remote locations around the globe and for testing for the presence of iodine additives in salts dispensed in those regions. PUBLIC HEALTH RELEVANCE: A highly sensitive (<1 ppb), portable instrument will be developed for the measurement of iodide and iodate in urine and table salt. The Rapid Iodine Analyzer will be an important new tool for use in addressing the problem of iodine deficiency disorders currently affecting 740 million people in 130 countries.