Field Portable Instrument for Iodide Analysis

用于碘化物分析的现场便携式仪器

• 批准号: 7535448
• 负责人: John W Birks
• 金额: $ 34.88万
• 依托单位: 2B TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7535448
• 关键词: Field; Portable; Instrument; Iodide; Analysis

DESCRIPTION (provided by applicant): Iodine deficiency disorder (IDD) has been identified by the World Health Organization as a serious global health problem affecting 740 million people in 130 countries. Iodine deficiency is the most common cause of preventable brain damage, with nearly 50 million people suffering some degree of IDD-related brain damage. IDD is preventable and treatable by iodization of table salt. Identification of individuals suffering from IDD and populations at risk requires the development of an instrument capable of measuring iodide in urine and both iodide and iodate in table salt. We propose to develop a small, lightweight, inexpensive instrument, the Rapid Iodine Analyzer (RIA), that will allow measurements of iodine present as either iodide or iodate. The instrument will be based on a novel and proprietary detection method successfully demonstrated in our Phase I grant. It will be highly automated and will require very little sample preparation. The portable instrument is expected to have a limit of detection of <1 ppb and to be free of interferences. Thus, the sensitivity will be adequate to diagnose patients as having moderate (20-49 ppb) or severe iodine deficiency (<20 ppb), as well as those having normal (100- 199 ppb) or excess iodine (>300 ppb) in their urine. Because of its low cost (<$2,000 retail), portability (<5 lb), and low power requirements (<6 watts), the RIA will be highly useful for assessing iodine deficiency in populations in remote locations around the globe and for testing for the presence of iodine additives in salts dispensed in those regions. PUBLIC HEALTH RELEVANCE: A highly sensitive (<1 ppb), portable instrument will be developed for the measurement of iodide and iodate in urine and table salt. The Rapid Iodine Analyzer will be an important new tool for use in addressing the problem of iodine deficiency disorders currently affecting 740 million people in 130 countries.

描述(申请人提供)：缺碘障碍(IDD)已被世界卫生组织确定为一个严重的全球健康问题，影响着130个国家的7.4亿人。缺碘是可预防的脑损伤最常见的原因，近5000万人遭受不同程度的与缺碘相关的脑损伤。碘缺乏病可以通过食盐加碘来预防和治疗。确定患有碘缺乏病的个人和处于危险中的人群需要开发一种能够测量尿碘和食盐中的碘化物和碘酸盐的仪器。我们建议开发一种小型、轻便、廉价的仪器--快速碘分析仪(RIA)，它将允许测量碘以碘化物或碘酸盐的形式存在。该仪器将基于我们在第一阶段拨款中成功演示的一种新颖的专有检测方法。这将是高度自动化的，只需要很少的样品准备。预计便携式仪器的检测极限为1ppb，并且不受干扰。因此，灵敏度将足以诊断为中度(20-49 ppb)或重度碘缺乏(&lt；20 ppb)的患者，以及那些尿碘正常(100-199 ppb)或过量(&gt；300 ppb)的患者。由于其低成本(零售2,000美元)、便携性(5磅)和低功率要求(6瓦)，RIA将非常有助于评估全球偏远地区人口的碘缺乏症，并测试这些地区分发的食盐中是否存在碘添加剂。与公共卫生有关：将开发一种高灵敏度(1 Ppb)的便携式仪器，用于测量尿液和食盐中的碘和碘酸盐。快速碘分析仪将是解决目前影响130个国家7.4亿人的缺碘性疾病问题的重要新工具。