A High Throughput System for Multichannel Neurophysiology

多通道神经生理学的高通量系统

• 批准号: 7053520
• 负责人: TIMOTHY J TUCKER
• 金额: $ 19.83万
• 依托单位: TUCKER-DAVIS TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-15 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7053520
• 关键词: communication; conditioning; electrodes; fasting; neurons; neurophysiology

DESCRIPTION (provided by applicant): Recent technical developments have made simultaneously recording the activity of many neurons possible. These experiments show great promise in both basic and applied research, illustrating the dynamic interplay between large populations of neurons as well as the potential for neuroprosthetic control of artificial limbs or restoring sensory input. To support this research, we will develop a very high throughput system for multichannel neurophysiology based on our existing System 3 hardware and software. This new design will utilize the best advantages of our existing system design and eliminate current bottlenecks. Our ultimate goals for this project are: (1) to streamline data acquisition by producing a dedicated system designed to process and record many channels of neurophysiological data, controlled and analyzed by a single monitor PC, and (2) to minimize post-hoc analysis of these very large data sets by allowing for efficient real-time signal conditioning, spike sorting, data display, and analysis on a novel new dedicated digital signal processing (DSP) platform. The high throughput data acquisition platform proposed here is designed to support and extend high-count multichannel investigations. Our DSP architecture is very well suited for this processing and as a foundation to the system we propose here, will serve as an enabling technology for acquiring and pre-processing large numbers of derived data sets from complex or high channel count neurophysiology recording systems. The successful delivery of a high throughput system for neurophysiology will increase data yield, speed analysis, reduce animal use, and allow fundamental questions about simultaneous neural activity and functional connectivity to be addressed.

描述（由申请人提供）：最近的技术发展使得同时记录许多神经元的活动成为可能。这些实验在基础研究和应用研究中都显示出巨大的前景，说明了大量神经元之间的动态相互作用，以及神经假体控制假肢或恢复感觉输入的潜力。为了支持这项研究，我们将基于我们现有的 System 3 硬件和软件开发一个用于多通道神经生理学的高通量系统。这种新设计将利用我们现有系统设计的最佳优势并消除当前的瓶颈。我们该项目的最终目标是：(1) 通过生产专用系统来简化数据采集，该专用系统旨在处理和记录多通道神经生理学数据，并由单个监控 PC 进行控制和分析；(2) 通过在新颖的专用数字信号处理 (DSP) 平台上实现高效的实时信号调节、尖峰排序、数据显示和分析，最大限度地减少对这些非常大的数据集的事后分析。这里提出的高通量数据采集平台旨在支持和扩展高计数多通道研究。我们的 DSP 架构非常适合这种处理，并且作为我们在此提出的系统的基础，将作为一种支持技术，用于从复杂或高通道数神经生理学记录系统中获取和预处理大量派生数据集。成功交付用于神经生理学的高通量系统将提高数据产量、加快分析速度、减少动物使用，并解决有关同步神经活动和功能连接的基本问题。