Microwire Arrays for Multichannel Neurophysiology

用于多通道神经生理学的微线阵列

• 批准号: 6931629
• 负责人: TIMOTHY J TUCKER
• 金额: $ 27.83万
• 依托单位: TUCKER-DAVIS TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-15 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6931629
• 关键词: biomedical equipment development; electrical impedance; electrodes; electronic recording system; laboratory rat; neural plasticity; neurophysiology; sensorimotor system

DESCRIPTION (provided by applicant): Chronically implanted microwire arrays are a simple and reliable tool for long-term multichannel neurophysiological recording and stimulation. Multichannel arrays increase data yield from individual animals and allow questions about higher brain function and functional connectivity to be addressed. These chronically implanted electrodes also allow for greater physical and behavioral freedom of the experimental subject, allowing investigators to perform recordings on awake, behaving subjects in more naturalistic settings. Finally, chronic recording techniques permit long-term access to a block of neural tissue, a fundamental advantage in studies on neural plasticity. Continuing development will provide an inexpensive, uniform, and dependable source for microwire arrays. New manufacturing approaches will allow for greater data yield, more precise electrode placement, consistent impedances across the array, better neural isolation and improved electrode geometry. Designs to improve ease of insertion and long-term biocompatibility will also be developed. Microwire array development is an enabling technology for research on sensory and motor mapping, functional electrical stimulation, chronic neural implants, and neural prostheses.

描述（由申请人提供）：长期植入的微导丝阵列是一种用于长期多通道神经生理记录和刺激的简单可靠的工具。多通道阵列增加了个体动物的数据产量，并允许解决有关高级大脑功能和功能连接的问题。这些长期植入的电极也允许实验对象有更大的身体和行为自由，允许研究人员在更自然的环境中对清醒的行为对象进行记录。最后，慢性记录技术允许长期进入一块神经组织，这是神经可塑性研究的一个基本优势。 持续的发展将为微丝阵列提供廉价、统一和可靠的来源。新的制造方法将允许更大的数据产量，更精确的电极放置，整个阵列的一致阻抗，更好的神经隔离和改进的电极几何形状。还将开发设计，以提高插入的便利性和长期的生物相容性。微线阵列的发展是一个使技术的研究感觉和运动映射，功能性电刺激，慢性神经植入物，神经假体。