A High Throughput System for Multichannel Neurophysiology

多通道神经生理学的高通量系统

• 批准号: 7220645
• 负责人: TIMOTHY J TUCKER
• 金额: $ 19.49万
• 依托单位: TUCKER-DAVIS TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-15 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7220645
• 关键词: Address; Animals; Applied Research; Architecture; Artificial limb procedure; Bite; Communication; Compatible; Complex; Computer software; Count; Critical Pathways; Data; Data Display; Data Set; Development; Devices; Digital Signal Processing; Electrodes; Fiber Optics; Foundations; Goals; Indium; Investigation; Limb Prosthesis; Link; Marketing; Memory; Monitor; Neurons; Noise; Numbers; Peripheral; Phase; Population; Process; Purpose; Research Personnel; Sensory; Series; Signal Transduction; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Sorting - Cell Movement; Speed; Standards of Weights and Measures; Support of Research; System; Technology; Testing; Time; base; computerized data processing; conditioning; data acquisition; density; design; digital; elastomeric; experience; neurophysiology; novel; programs; relating to nervous system; research study; size

DESCRIPTION (provided by applicant): Recent technical developments have made simultaneously recording the activity of many neurons possible. These experiments show great promise in both basic and applied research, illustrating the dynamic interplay between large populations of neurons as well as the potential for neuroprosthetic control of artificial limbs or restoring sensory input. To support this research, we will develop a very high throughput system for multichannel neurophysiology based on our existing System 3 hardware and software. This new design will utilize the best advantages of our existing system design and eliminate current bottlenecks. Our ultimate goals for this project are: (1) to streamline data acquisition by producing a dedicated system designed to process and record many channels of neurophysiological data, controlled and analyzed by a single monitor PC, and (2) to minimize post-hoc analysis of these very large data sets by allowing for efficient real-time signal conditioning, spike sorting, data display, and analysis on a novel new dedicated digital signal processing (DSP) platform. The high throughput data acquisition platform proposed here is designed to support and extend high-count multichannel investigations. Our DSP architecture is very well suited for this processing and as a foundation to the system we propose here, will serve as an enabling technology for acquiring and pre-processing large numbers of derived data sets from complex or high channel count neurophysiology recording systems. The successful delivery of a high throughput system for neurophysiology will increase data yield, speed analysis, reduce animal use, and allow fundamental questions about simultaneous neural activity and functional connectivity to be addressed.

描述（由申请人提供）：最近的技术发展使得同时记录许多神经元的活动成为可能。这些实验在基础研究和应用研究方面都显示出巨大的前景，说明了大量神经元之间的动态相互作用，以及神经假肢控制或恢复感觉输入的潜力。为了支持这项研究，我们将在现有的System 3硬件和软件的基础上开发一个非常高通量的多通道神经生理学系统。这项新设计将充分利用我们现有系统设计的最佳优点，并消除目前的瓶颈。我们对这个项目的最终目标是：（1）通过生产专用系统来简化数据采集，该专用系统被设计成处理和记录由单个监视器PC控制和分析的许多通道的神经生理数据，以及（2）通过允许有效的实时信号调节、尖峰分选、数据显示，并对一种新型专用数字信号处理（DSP）平台进行了分析。这里提出的高通量数据采集平台旨在支持和扩展高计数多通道调查。我们的DSP架构非常适合这种处理，作为我们在这里提出的系统的基础，将作为一种使能技术，用于从复杂或高通道数神经生理记录系统中获取和预处理大量派生数据集。神经生理学高通量系统的成功交付将增加数据产量，加快分析速度，减少动物使用，并允许解决有关同时神经活动和功能连接的基本问题。