A TRIAL OF MYCOPHENOLATE MOFETIL IN MYASTHENIA GRAVIS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to test the hypothesis that mycophenolate mofetil (2.5 g/d) in combination with prednisone (20 mg/d) provides better control of signs and symptoms than prednisone alone in the initial management of myasthenia gravis (MG). A 6 month open-label extension will supply further information about the safety and tolerability of MM at doses ranging from 2.5-3 g/d, and will give some preliminary information about the frequency with which prednisone can be tapered or even discontinued in patients maintained on MM.