Functional characterization and therapeutic targeting of the novel long noncoding RNA MYCN-AS

新型长非编码RNA MYCN-AS的功能表征和治疗靶向

• 批准号: nhmrc : 1099025
• 负责人: A/Pr Marcel Dinger
• 金额: $ 44.36万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-characterization-therapeutic-mycn-as/662416
• 关键词: Functional; characterization; therapeutic; targeting; novel

Cancer is the most common cause of death from diseases in children. Neuroblastoma is the most common solid tumour in early childhood. In this application, we will establish the role of gene amplification of a novel long non-protein-coding RNA in blocking tumour suppressor gene expression and promoting neuroblastoma progression. We will also establish the anti-cancer efficacy of a novel therapy targeting the long non-protein-coding RNA.

癌症是儿童疾病死亡的最常见原因。神经母细胞瘤是儿童早期最常见的实体瘤。在本申请中，我们将建立一种新的长非蛋白编码RNA的基因扩增在阻断肿瘤抑制基因表达和促进神经母细胞瘤进展中的作用。我们还将确定一种针对非蛋白质编码长RNA的新型疗法的抗癌功效。