MicroRNA regulation of sex determination and gonad development.

MicroRNA 调节性别决定和性腺发育。

• 批准号: nhmrc : 631460
• 负责人: A/Pr Marcel Dinger
• 金额: $ 34.55万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/microrna-regulation-sex-gonad-development/95342
• 关键词: MicroRNA; regulation; sex; determination; gonad

Sex determination, the decision to develop into either boy or girl, influences most aspects of our lives. Consequently, disorders of sexual development (~1% of births), resulting in genital abnormalities, infertility and often cancer, are extremely traumatic for the individual. The molecular basis of these disorders is not well understood. This project will identify new factors important for sex determination and therefore will improve diagnosis and clinical care for the patients.

性别决定，即决定是男孩还是女孩，影响着我们生活的方方面面。因此，性发育障碍（约占新生儿的1%）导致生殖器异常、不孕症，通常还会导致癌症，这对个人造成极大的创伤。这些疾病的分子基础尚不清楚。该项目将确定对性别决定有重要影响的新因素，从而将改善对患者的诊断和临床护理。