Biodemography of Disease and Death in Moscow

莫斯科疾病和死亡的生物人口学

• 批准号: 7100836
• 负责人: James W. Vaupel
• 金额: $ 49.32万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7100836
• 关键词: Commonwealth of Independent States; arrhythmia; circadian rhythms; clinical research; disease /disorder proneness /risk; early experience; epidemiology; health behavior; health surveys; human middle age (35-64); human mortality; human old age (65+); human subject; international cooperation; interview; longitudinal human study; prognosis; psychological stressor; quality of life; socioeconomics; statistics /biometry; urban poverty area

DESCRIPTION (provided by applicant): The general goals of the proposed research are to: (1) Investigate whether 24-hour Hotter monitoring can feasibly be added to biodemographic surveys and whether the Holler information contributes to better measurement of physiological toll and understanding of the causal mechanisms that link individual characteristics and socio-economic conditions with health and survival, and (2) Provide a database that can be used by ourselves and others to shed light on the impact of stress on the poor health and high mortality of middle-aged and elderly Russians. The proposed research builds upon a promising small-scale pilot project, the 2002-2003 Moscow Pilot Study. To pursue these general goals we propose to conduct a demographic and health survey of 2,000 men and women aged 55+ who reside in Moscow. The study questionnaire will include information about early life conditions, socio-economic status, health and quality of life, health behaviors, physical and cognitive ability, and psychological stress. Data on various biomarkers reflecting multi-system body functioning will be collected. Twenty-four-hour Holter monitoring will provide multi dimensional time series reflecting heart rate variability, arrhythmia events, sleep and other circadian (day- night) characteristics. We propose to study these data, using standard statistical methods of regression analysis, with a focus on determining the incremental value of Holter monitoring as an additional source of information in biodemographic research. We plan to conduct a follow-up interview of all survey participants approximately 2.5 years after the first interview and to study these longitudinal data, using standard statistical methods of survival analysis, with a focus on determining the incremental value of Holter information to predict morbidity and mortality. Finally, we propose to prepare and promptly release a user- friendly dataset that includes all the data we collect. The study will attempt to determine the most informative parameters for predicting health risk for future use in research and public health practice.

描述（由申请人提供）：拟议的研究的一般目标是：（1）调查是否可以将24小时的热监测可行地添加到生物人口统计学调查中，以及HOLLER信息是否有助于更好地测量生理损失，并理解对其他人的特征和社会经济条件，并将其与您的健康特征和社会态度联系起来，并将其与您自己联系起来，并将其与您自己联系起来。压力对中年和老年人的健康状况不佳和高死亡率的影响。拟议的研究基于一个有希望的小型试点项目，即2002 - 2003年莫斯科试点研究。为了实现这些一般目标，我们建议对居住在莫斯科的2,000名55岁以上的男女进行人口统计和健康调查。该研究问卷将包括有关早期生活条件，社会经济地位，健康和生活质量，健康行为，身体和认知能力以及心理压力的信息。将收集有关反映多系统身体功能的各种生物标志物的数据。二十四小时的手机监视将提供多维的时间序列，以反映心率变异性，心律不齐事件，睡眠和其他昼夜节律（日夜）特征。我们建议使用标准的回归分析方法研究这些数据，重点是确定Holter监视的增量值，作为生物人口统计学研究中的其他信息来源。我们计划使用标准的生存分析统计方法对所有调查参与者进行所有调查参与者的后续访谈，并研究这些纵向数据，重点是确定Holter信息的增量价值以预测发病率和死亡率。最后，我们建议准备并迅速发布一个用户友好的数据集，其中包括我们收集的所有数据。该研究将尝试确定预测研究和公共卫生实践中未来使用的健康风险的最有用的参数。