DRD4 and Behavior in the Oldest-old

DRD4 和高龄老人的行为

• 批准号: 7121496
• 负责人: ROBERT K Moyzis
• 金额: $ 53.95万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7121496
• 关键词: alleles; attention; behavior; behavior disorders; behavioral /social science research tag; behavioral genetics; cell bank /registry; clinical research; exploratory behavior; family genetics; generation difference; genetic polymorphism; genetic registry /resource /referral center; genotype; human subject; human very old age (85+); longevity; molecular genetics; neuropsychological tests; nucleic acid sequence; personality; personality tests; phenotype; psychological aspect of aging; quality of life

DESCRIPTION(provided by applicant): The goal of this project is to create a repository of cell lines/DNA from over 500 well-characterized subjects aged 90 or more and to begin investigations of the relationship between specific genes and behavior in this "oldest-old" population. Specifically, we will investigate the effect of DRD4 allelic variation on the personality trait of novelty-seeking and it's relationship to behavior/quality of life in this cohort. The resource generated by this study will allow us to facilitate genetic research for scientists around the country, working in longevity and the clinical, behavioral and functional status of our oldest citizens. We have assembled a multidisciplinary team, consisting of human molecular geneticists, neurologists/epidemiologists, statistical geneticists and clinical psychologists to address the following: Specific Aim 1 - Development of a genetic repository of the oldest-old. ]'o develop a cell line/DNA bank of a population-based cohort of individuals aged 90 and older (N=560) who are well characterized with medical history, medication use, neuropsychological testing, and neurological examinations. Specific Aim 2 - To test the hypothesis that specific non-4R alleles of the DRD4 gene are associated with behaviors that effect quality of life in this cohort. Personality questionnaires and a simplified attentional network test (ANT) will be obtained as adjuncts to the current test battery/histories of this oldest-old cohort. Genotyping/sequencing of the DRD4 locus will be used to test if alleles associated with novelty-seeking and behavioral disorders in younger individuals are associated with improved quality of life in this oldest-old population. Specific Aim 3 - To obtain detailed pedigree information on this cohort as an adjunct to ongoing evaluations. In order to make this oldest-old cohort of maximum value for future genetic studies, we will obtain multigenerational pedigrees with defined, relevant phenotypic information.

描述(由申请者提供)：该项目的目标是创建一个来自500多名90岁或以上特征良好的受试者的细胞系/DNA的储存库，并开始研究这一“最老的”群体中特定基因与行为之间的关系。具体地说，我们将调查DRD4等位基因变异对该队列中寻求新奇的人格特质的影响及其与行为/生活质量的关系。这项研究产生的资源将使我们能够促进全国各地科学家的基因研究，研究我们最年长公民的长寿和临床、行为和功能状况。我们已经组建了一个由人类分子遗传学家、神经学家/流行病学家、统计遗传学家和临床心理学家组成的多学科团队，以解决以下问题： 具体目标1--开发最古老的遗传库。建立以人群为基础的90岁及以上(N=560)老年人的细胞系/DNA库，这些人具有良好的病史、用药情况、神经心理测试和神经学检查。 特定目的2--验证DRD4基因的特定非4R等位基因与影响该队列中生活质量的行为相关的假设。将获得人格问卷和简化的注意力网络测试(ANT)，作为这一最古老队列的当前测试组合/历史的辅助工具。对DRD4基因座的基因分型/测序将被用来测试与年轻个体的新奇追求和行为障碍相关的等位基因是否与这个年龄最大的老年人群生活质量的改善有关。 具体目标3--获得关于这一群体的详细血统信息，作为正在进行的评估的补充。为了使这个最古老的队列对未来的遗传学研究具有最大的价值，我们将获得具有明确的、相关的表型信息的多代家系。