DRD4 and Behavior in the Oldest-old

DRD4 和高龄老人的行为

• 批准号: 7121496
• 负责人: ROBERT K Moyzis
• 金额: $ 53.95万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7121496
• 关键词: alleles; attention; behavior; behavior disorders; behavioral /social science research tag; behavioral genetics; cell bank /registry; clinical research; exploratory behavior; family genetics; generation difference; genetic polymorphism; genetic registry /resource /referral center; genotype; human subject; human very old age (85+); longevity; molecular genetics; neuropsychological tests; nucleic acid sequence; personality; personality tests; phenotype; psychological aspect of aging; quality of life

DESCRIPTION(provided by applicant): The goal of this project is to create a repository of cell lines/DNA from over 500 well-characterized subjects aged 90 or more and to begin investigations of the relationship between specific genes and behavior in this "oldest-old" population. Specifically, we will investigate the effect of DRD4 allelic variation on the personality trait of novelty-seeking and it's relationship to behavior/quality of life in this cohort. The resource generated by this study will allow us to facilitate genetic research for scientists around the country, working in longevity and the clinical, behavioral and functional status of our oldest citizens. We have assembled a multidisciplinary team, consisting of human molecular geneticists, neurologists/epidemiologists, statistical geneticists and clinical psychologists to address the following: Specific Aim 1 - Development of a genetic repository of the oldest-old. ]'o develop a cell line/DNA bank of a population-based cohort of individuals aged 90 and older (N=560) who are well characterized with medical history, medication use, neuropsychological testing, and neurological examinations. Specific Aim 2 - To test the hypothesis that specific non-4R alleles of the DRD4 gene are associated with behaviors that effect quality of life in this cohort. Personality questionnaires and a simplified attentional network test (ANT) will be obtained as adjuncts to the current test battery/histories of this oldest-old cohort. Genotyping/sequencing of the DRD4 locus will be used to test if alleles associated with novelty-seeking and behavioral disorders in younger individuals are associated with improved quality of life in this oldest-old population. Specific Aim 3 - To obtain detailed pedigree information on this cohort as an adjunct to ongoing evaluations. In order to make this oldest-old cohort of maximum value for future genetic studies, we will obtain multigenerational pedigrees with defined, relevant phenotypic information.

描述（由申请人提供）：本项目的目标是从500多名90岁或以上的受试者中创建细胞系/DNA库，并开始研究这一“最老”人群中特定基因与行为之间的关系。具体而言，我们将调查DRD 4等位基因变异对新奇寻求人格特质的影响及其与该队列中行为/生活质量的关系。这项研究所产生的资源将使我们能够促进全国各地科学家的遗传研究，致力于长寿以及我们最年长公民的临床，行为和功能状态。我们组建了一个多学科团队，由人类分子遗传学家，神经学家/流行病学家，统计遗传学家和临床心理学家组成，以解决以下问题： 具体目标1 -建立最年长者的基因库。·开发一个基于人群的90岁及以上人群（N=560）的细胞系/DNA库，这些人群具有良好的病史、药物使用、神经心理学测试和神经系统检查特征。 具体目标2 -检验DRD 4基因的特定非4 R等位基因与影响该队列生活质量的行为相关的假设。将获得个性问卷和简化注意力网络测试（ANT），作为该年龄最大队列的当前测试组合/历史的参考。DRD 4基因座的基因分型/测序将用于测试与年轻个体中的新奇寻求和行为障碍相关的等位基因是否与该最年长人群中的生活质量改善相关。 具体目标3 -获得该队列的详细谱系信息，作为正在进行的评价的辅助。为了使这个年龄最大的队列对未来的遗传研究具有最大价值，我们将获得具有定义的相关表型信息的多代家系。