Pittsburgh Mind-Body Center-II

描述(申请人提供)：从2000年5月开始，我们一直是匹兹堡心身中心(PMBC-I)，致力于：a)了解有助于各种身体疾病的发生和康复的共同心理、行为和心理生物学途径；以及b)提供关于心身关系和健康的本地和全国培训资源。我们现在提议通过“心身互动与健康：研究基础设施计划(RFA OB-03-004)”将PMBC-II再延续五年。根据我们过去三年积累的研究经验和成果，我们打算从三个方面对指导我们PMBC-I工作的共享路径模型进行进一步评估：1)拆解模型中的关键相关概念，对其进行更微观的分析；2)测试生命过程对路径的影响；3)将共享路径模型扩展到PMBC-I中尚未研究的疾病。为了开展这项工作，我们将有5个研究核心，它们将以协调的方式运作：(A)数据管理和统计资源；(B)心理社会和健康行为评估；(C)睡眠评估和资源；以及(D)生物和生物医学测量。为了继续我们的研究开发和培训任务，我们将建立三个基础设施部分：创新先导研究、学院发展和暑期学院。针对PMBC-II的第一个目标，一个类似R01的项目(压力和大脑反应路径)研究了支撑心血管对急性压力的反应的中枢神经系统。PMBC-II的意义在于认识到许多关键的心身概念在不同疾病之间可能是相似的；由于大多数资助机构的特殊性，主流卫生研究中没有跨疾病研究的家；以及理解解释其他不直接属于PMBC工作的疾病的共同途径有可能产生倍增效应。第二期项目管理委员会提供的基础设施将有助于整合和促进对中心旨在解决的主题和研究问题的研究。来自主办机构的实物支持将使我们能够利用RFA提供的资金来扩大中心的活动，否则这些活动是不可能的。

DESCRIPTION (provided by applicant): Starting May 2000 we have been functioning as the Pittsburgh Mind-Body Center (PMBC-I) dedicated to: a) understanding shared psychological, behavioral, and psychobiological pathways that contribute to the onset of and recovery from diverse physical illnesses; and b) providing a training resource locally and nationally regarding mind-body relationships and health. We are now proposing to continue PMBC-II for an additional five years through the "Mind-Body Interactions and Health: Research Infrastructure Program (RFA OB-03- 004)". Based upon our accumulated research experience and accomplishments of the last 3 years, we intend to evaluate further the shared pathways model guiding our PMBC-I work in three ways: 1) unpacking key relevant concepts in the model, decomposing them and subjecting them to more micro-level analysis; 2) testing the influence of the life course on the pathways; and 3) extending the shared pathways model to diseases not already studied in PMBC-I. To carry out this work, we will have 5 research cores that will function in an orchestrated fashion: (A) Data Management and Statistical Resources; (B) Psychosocial and Health Behavior Assessment; (C) Sleep Assessment and Resources; and (D) Biological and Biomedical Measurement. To continue our research development and training mission, we will establish three infrastructure components: Innovative Pilot Research; Faculty Development; and Summer Institutes. Addressing the first aim of PMBC-II, an R01-like project (Stress and Brain Pathways to Reactivity) examines the central nervous system underpinning of cardiovascular reactivity to acute stress. The significance of PMBC-II rests upon the realization that many of the key mind-body concepts may be similar across diseases; that there is no home in mainstream health research for cross-disease research because of the specificity of most funding agencies; and that there is a potential for a multiplier effect from understanding shared pathways for explicating other diseases not directly part of the PMBC work. The infrastructure provided by PMBC-II will serve to integrate and promote research on the themes and research questions that the Center is designed to address. Support-in-kind from the host institutions will enable us to leverage the funds provided by the RFA to expand Center activities that would not otherwise be possible.