Pittsburgh Mind-Body Center-II

描述（由申请人提供）：从2000年5月开始，我们一直作为匹兹堡身心中心（PMBC-I）运作，致力于：a)理解共同的心理、行为和心理生物学途径，这些途径有助于各种身体疾病的发病和康复；b)在当地和全国范围内提供关于身心关系和健康的培训资源。我们现在提议通过“身心相互作用与健康：研究基础设施计划（RFA OB-03- 004）”，将PMBC-II项目再延长五年。基于我们过去3年积累的研究经验和成果，我们打算从三个方面进一步评估指导PMBC-I工作的共享路径模型：1)解开模型中的关键相关概念，对其进行分解，并对其进行更微观层面的分析；2)测试生命历程对路径的影响；3)将共享通路模型扩展到PMBC-I中尚未研究的疾病。为了开展这项工作，我们将有5个研究核心，它们将以协调的方式发挥作用：(A)数据管理和统计资源；(B)心理社会和健康行为评估；(C)睡眠评估和资源；(D)生物和生物医学测量。为了继续我们的研究发展和培训使命，我们将建立三个基础设施组成部分：创新试点研究；教师发展;和暑期学院。为了解决PMBC-II的第一个目标，一个类似r01的项目（压力和大脑反应途径）研究了心血管对急性压力反应的中枢神经系统基础。PMBC-II的意义在于认识到许多关键的身心概念可能在疾病中是相似的；由于大多数资助机构的特殊性，跨疾病研究在主流卫生研究中没有立足之地；并且通过理解解释不直接属于PMBC工作的其他疾病的共同途径，有可能产生乘数效应。PMBC-II提供的基础设施将用于整合和促进对该中心旨在解决的主题和研究问题的研究。来自主办机构的实物支持将使我们能够利用亚洲区域基金提供的资金，扩大本中心原本无法开展的活动。

DESCRIPTION (provided by applicant): Starting May 2000 we have been functioning as the Pittsburgh Mind-Body Center (PMBC-I) dedicated to: a) understanding shared psychological, behavioral, and psychobiological pathways that contribute to the onset of and recovery from diverse physical illnesses; and b) providing a training resource locally and nationally regarding mind-body relationships and health. We are now proposing to continue PMBC-II for an additional five years through the "Mind-Body Interactions and Health: Research Infrastructure Program (RFA OB-03- 004)". Based upon our accumulated research experience and accomplishments of the last 3 years, we intend to evaluate further the shared pathways model guiding our PMBC-I work in three ways: 1) unpacking key relevant concepts in the model, decomposing them and subjecting them to more micro-level analysis; 2) testing the influence of the life course on the pathways; and 3) extending the shared pathways model to diseases not already studied in PMBC-I. To carry out this work, we will have 5 research cores that will function in an orchestrated fashion: (A) Data Management and Statistical Resources; (B) Psychosocial and Health Behavior Assessment; (C) Sleep Assessment and Resources; and (D) Biological and Biomedical Measurement. To continue our research development and training mission, we will establish three infrastructure components: Innovative Pilot Research; Faculty Development; and Summer Institutes. Addressing the first aim of PMBC-II, an R01-like project (Stress and Brain Pathways to Reactivity) examines the central nervous system underpinning of cardiovascular reactivity to acute stress. The significance of PMBC-II rests upon the realization that many of the key mind-body concepts may be similar across diseases; that there is no home in mainstream health research for cross-disease research because of the specificity of most funding agencies; and that there is a potential for a multiplier effect from understanding shared pathways for explicating other diseases not directly part of the PMBC work. The infrastructure provided by PMBC-II will serve to integrate and promote research on the themes and research questions that the Center is designed to address. Support-in-kind from the host institutions will enable us to leverage the funds provided by the RFA to expand Center activities that would not otherwise be possible.