Early Life Adversity, Sleep, and Cardiovascular Risk in Black and White Men

黑人和白人的早年逆境、睡眠和心血管风险

• 批准号: 8531339
• 负责人: KAREN MATTHEWS
• 金额: $ 68.05万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531339
• 关键词: 6 year old; Academic achievement; Accounting; Adolescence; Adult; Advocate; Affect; Age; American; American Heart Association; Behavior; Behavioral; Biological Markers; Blood Pressure; Blood Vessels; Body Size; Cardiovascular Diseases; Cardiovascular system; Censuses; Cessation of life; Characteristics; Child; Child Abuse and Neglect; Childhood; Cholesterol; Communities; Crime; Deterioration; Development; Discipline; Disease; Economics; Enrollment; Environment; Ethnic Origin; Event; Exhibits; Exposure to; Family; Generations; Glucose; Goals; Health; Health behavior; Healthy People 2020; Household; Hypertension; Individual; Intervention; Knowledge; Label; Life; Life Cycle Stages; Life Experience; Longevity; Longitudinal Studies; Measures; Metabolic syndrome; Mus; Neighborhoods; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Parenting behavior; Parents; Participant; Pattern; Physical activity; Premature Mortality; Psychosocial Factor; Race; Resources; Risk Factors; Sleep; Socioeconomic Status; Solid; Staging; Stress; Stroke; Testing; Time; Violence; Weather; Woman; Youth; actigraphy; base; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular risk factor; clinically relevant; critical period; design; early life exposure; experience; first grade; good diet; health disparity; health equity; heart rate variability; improved; low socioeconomic status; male; men; middle age; mortality; parental monitoring; peer; population based; prevent; psychosocial; public health relevance; racial and ethnic disparities; skills; social; social skills; stem

DESCRIPTION (provided by applicant): Black men suffer disproportionately from premature mortality and cardiovascular disease (CVD) compared to their white counterparts, perhaps in part due to blacks' greater exposure to social and economic adversity across the life span as suggested by the weathering hypothesis. This application suggests that (a) black-white differences in CVD in adulthood stem from cumulative adversity correlated with race much earlier in life; and (b) early life exposures at the individual, family, and neighborhood level mus be considered simultaneously. Not emphasized in the weathering hypothesis is that intra- and inter-personal and cultural resources also may accumulate over the life course (labeled reserve capacity) and moderate effects of early life adversity; and that there may also be a critical perio exposure to adverse life events. Sleep may be an important factor here because of its likely relation to race and socioeconomic status (SES), and possibly to CVD events. This application focuses on the developmental antecedents of sleep, optimal cardiovascular (CV) health (defined by AHA criteria), and CVD risk in a population-based study of middle-aged black and white men who have been followed since they were enrolled in the first grade. They have been assessed repeatedly for health behaviors and academic and social competence; parent health behaviors, parenting practices, and household SES; and neighborhood characteristics, including census track SES, violence exposure, and community cohesiveness and involvement; these measures have been summarized into developmentally appropriate periods. In 300 men now in their late thirties, we propose to collect measures of CV biomarkers and psychosocial risk factors and sleep to test the following: 1) the extent of black/white differences in sleep, optimal CV health, and CVD risk, and sleep; 2) whether early adverse family and neighborhood environments, particularly during adolescence, predict adult optimal CV health, CVD risk, and sleep; and 3) if reserve capacity reduces the impact of early adverse environments. Knowledge gained from this project may identify the early life experiences and their timing that render black men particularly vulnerable to later CVD.

描述（由申请人提供）：与白色男性相比，黑人男性过早死亡和心血管疾病（CVD）的比例更高，这可能部分是由于黑人在整个生命周期中更容易受到社会和经济逆境的影响，正如风化假说所建议的那样。这一应用表明，（a）成年期CVD的黑人-白人差异源于生命早期与种族相关的累积逆境;（B）必须同时考虑个人、家庭和社区水平的早期生活暴露。风化假说没有强调的是，内部和人际和文化资源也可能在生命过程中积累（标记为储备能力）和早期生活逆境的适度影响;也可能有一个关键时期暴露于不利的生活事件。睡眠可能是一个重要的因素，因为它可能与种族和社会经济地位（SES）有关，也可能与CVD事件有关。该应用程序的重点是睡眠，最佳心血管（CV）健康（由AHA标准定义）和心血管疾病风险的发展前因在中年黑人和白色男性的人群为基础的研究谁一直在跟踪，因为他们在一年级入学。他们已被反复评估的健康行为和学术和社会能力;父母的健康行为，养育子女的做法，和家庭SES;和邻里特征，包括人口普查跟踪SES，暴力暴露，社区凝聚力和参与;这些措施已被总结为发展适当的时期。在300名30多岁的男性中，我们建议收集心血管生物标志物和心理社会风险因素以及睡眠的测量结果，以测试以下内容：1）黑人/白色人在睡眠、最佳心血管健康和心血管疾病风险以及睡眠方面的差异程度; 2）早期不利的家庭和邻里环境，特别是在青春期，是否预测成年后最佳的心血管健康、心血管疾病风险和睡眠;以及3）储备容量是否减少了早期不利环境的影响。从这个项目中获得的知识可以确定早期的生活经历和他们的时间，使黑人男性特别容易受到后来的CVD。