Centers for Autism & Develop Disabilities Resarch & Epidemiol:A Case-Cohort Study

自闭症中心

• 批准号: 7226354
• 负责人: Craig J Newschaffer
• 金额: $ 167.29万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7226354
• 关键词: autism; behavioral /social science research tag; behavioral genetics; clinical research; comorbidity; cooperative study; developmental disease /disorder; early experience; human subject; mental health epidemiology; preschool child (1-5)

DESCRIPTION (provided by applicant): Autism Spectrum Disorders (ASD) are severe, life-long neurodevelopmental disorders that confer considerable impairment to individuals as well as a substantial burden to their families. Little is known about the prevalence or correlates of ASDs. Little high quality information is available regarding the phenotypic variation among individuals with ASDs, prevalence of co-morbid conditions, and risk factors that might be related to the development of ASDs. The Centers for Autism and Developmental Disabilities Research and Epidemiology were established in 2001 to investigate causes and correlates of autism. The focus of this second funding cycle is to conduct a multi-site collaborative epidemiologic study to investigate risk and causal factors for Autism Spectrum Disorders (ASDs) and phenotypic subgroups of ASDs using a population-based case-cohort study design. Six sites (California, Maryland, North Carolina, Pennsylvania, Colorado, and Georgia) will collaborate to enroll 2700 children and their families over the 5-year study period. Each site will include approximately 150 children with ASD, 150 with other neurodevelopmental disorders, and 150 general population controls to address specific hypotheses in six broad domains: 1) phenotypic variation in ASD, including the pattern of clustering of core symptoms, timing of onset, cognitive status, and presence of medical and psychiatric co- morbidities; 2) gastrointestinal features that may be associated with ASD, 3) candidate genes and genetic variation among individuals with ASD and how they interact with environmental risk factors, 4) potential for parental infection, immune function, and autoimmunity to be associated with increased ASD risk, 5) potential for parental hormonal and reproductive characteristics to be associated with increased ASD risk, and 6) potential for sociodemographic and lifestyle factors to be associated with increased ASD risk. To address these goals, this study will conduct developmental assessments on the children and collect extensive data on the pre- and perinatal health and environment of the children and their parents via interviews, medical record review, and the collection of biologic samples. This large study of ASD will improve our understanding of how autism differs phenotypically from other disabilities and from typical development. It will also help identify potential risk factors for autism that deserve more attention.

描述（由申请人提供）：自闭症谱系障碍（ASD）是严重的，终身的神经发育障碍，给个人带来相当大的损害，也给他们的家庭带来沉重的负担。人们对自闭症的患病率及其相关因素知之甚少。关于自闭症个体的表型差异、共病的患病率以及可能与自闭症发展相关的危险因素，目前的高质量信息很少。自闭症和发育障碍研究与流行病学中心成立于2001年，旨在调查自闭症的原因和相关因素。第二个资助周期的重点是开展一项多站点协作流行病学研究，以基于人群的病例队列研究设计来调查自闭症谱系障碍（asd）的风险和病因因素以及asd的表型亚群。六个地点（加利福尼亚州，马里兰州，北卡罗来纳州，宾夕法尼亚州，科罗拉多州和佐治亚州）将在5年的研究期间合作招募2700名儿童及其家庭。每个站点将包括大约150名ASD患儿、150名其他神经发育障碍患儿和150名普通人群对照，以解决六个广泛领域的特定假设：1)ASD的表型变异，包括核心症状的聚类模式、发病时间、认知状态以及医学和精神合并症的存在；2)可能与ASD相关的胃肠道特征，3)ASD个体之间的候选基因和遗传变异及其与环境风险因素的相互作用，4)亲代感染、免疫功能和自身免疫与ASD风险增加相关的可能性，5)亲代激素和生殖特征与ASD风险增加相关的可能性，6)社会人口和生活方式因素与ASD风险增加相关的可能性。为了实现这些目标，本研究将对儿童进行发育评估，并通过访谈，医疗记录审查和生物样本收集收集大量关于儿童及其父母产前和围产期健康和环境的数据。这项关于自闭症谱系障碍的大型研究将提高我们对自闭症与其他残疾和典型发育在表型上的不同的理解。它还将有助于确定值得更多关注的自闭症潜在风险因素。