Prenatal Antimicrobial Agent Exposure, Fetal Androgens and ASD Risk
产前抗菌药物暴露、胎儿雄激素和自闭症谱系障碍 (ASD) 风险
基本信息
- 批准号:9116852
- 负责人:
- 金额:$ 15.65万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-08-01 至 2018-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAgeAndrogensAutistic DisorderAutomobile DrivingBehaviorBiological MarkersBirthBrainCenters for Disease Control and Prevention (U.S.)ChildClinical DataCohort StudiesComplexDataData CollectionEndocrine DisruptorsEnrollmentEnvironmental Risk FactorEtiologyExposure toFemaleFetusGenderGene ExpressionGeneticGenomicsGonadal Steroid HormonesHealthInvestigationLifeLiquid substanceMeasuresMeconiumMediatingMediator of activation proteinMothersNeonatalOral cavityOutcomePathway interactionsPerinatal ExposurePregnancyPrevalencePublic HealthRecurrenceResearchResearch PersonnelRiskRisk FactorsSamplingSiblingsSoapsStructureTeratogensTestosteroneTimeToothpasteTriclosanTwin Multiple BirthUmbilical Cord BloodUnited StatesUrineandrogenicantimicrobial drugautism spectrum disorderboyscohortdisorder riskenvironmental chemicalfetalgender differencegender disparitygirlsinterestmaleneuropathologynovelpersonal care productsprenatalprenatal exposureprospectiveracial and ethnicrelating to nervous systemsocioeconomicstriclocarban
项目摘要
DESCRIPTION (provided by applicant): Autism spectrum disorders (ASDs) are a major public health concern in the United States affecting more than 1% of the nation's children in all racial, ethnic, and socioeconomic groups. The male-to-female prevalence ratio of roughly 4:1 in ASD is a well-recognized, but poorly-understood, phenomenon. An explicit focus on potential etiologic pathways consistent with this gender difference should be a priority in attempts to elucidate ASD causal mechanisms, including those amenable to environmental influence. Androgens, in particular testosterone, produced during pregnancy act on the brain to produce permanent gender differences in structure and function. Some researchers have hypothesized that ASD is an extreme presentation of "male brain," with fetal testosterone as the possible determining factor. Few endocrine disrupting chemicals are known to act on androgens; however, triclosans and triclocarbans (TCS/TCC) have been shown to have androgenic potential and are now widely used in liquid soap, toothpaste, mouth rinse, and other personal care products. Capitalizing on the availability of stored biosamples from a prospective cohort study of 213 mothers of children with ASD at the start of a subsequent pregnancy, we propose to assess prenatal TCS/TCC exposure in maternal prenatal urine samples and fetal testosterone levels in both cord blood and meconium and then and correlate these measures with ASD-related outcomes evaluated at 12 mos and 36 mos of age in the children born into the cohort. Fetal testosterone level will be explored as a potential mediating and/or moderating factor in associations between TCS/TCC and early ASD-related outcomes. The study will investigate a potentially avoidable environmental ASD risk factor, provide evidence related to an etiologic mechanism that comports with the observed ASD gender ratio, and generate i data on a fetal testosterone levels as assessed in meconium.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Craig J Newschaffer其他文献
Craig J Newschaffer的其他文献
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{{ truncateString('Craig J Newschaffer', 18)}}的其他基金
Prenatal Exposure to Endocrine Disrupting Chemical Mixtures and ASD Risk
产前接触内分泌干扰化学混合物和自闭症谱系障碍 (ASD) 风险
- 批准号:
10020188 - 财政年份:2017
- 资助金额:
$ 15.65万 - 项目类别:
Prenatal Exposure to Endocrine Disrupting Chemical Mixtures and ASD Risk
产前接触内分泌干扰化学混合物和自闭症谱系障碍 (ASD) 风险
- 批准号:
9338961 - 财政年份:2017
- 资助金额:
$ 15.65万 - 项目类别:
An ASD Enriched Risk (ASD-ER) ECHO Cohort
ASD 丰富风险 (ASD-ER) ECHO 队列
- 批准号:
9726807 - 财政年份:2016
- 资助金额:
$ 15.65万 - 项目类别:
An ASD Enriched Risk (ASD-ER) ECHO Cohort
ASD 丰富风险 (ASD-ER) ECHO 队列
- 批准号:
10018528 - 财政年份:2016
- 资助金额:
$ 15.65万 - 项目类别:
Prenatal Antimicrobial Agent Exposure, Fetal Androgens and ASD Risk
产前抗菌药物暴露、胎儿雄激素和自闭症谱系障碍 (ASD) 风险
- 批准号:
8917642 - 财政年份:2015
- 资助金额:
$ 15.65万 - 项目类别:
Ethics of Communicating Scientific Findings on Autism Risk
传播自闭症风险科学发现的伦理
- 批准号:
7677590 - 财政年份:2009
- 资助金额:
$ 15.65万 - 项目类别:
Early Autism Risk Longitudinal Investigation (EARLI) Network
早期自闭症风险纵向调查 (EARLI) 网络
- 批准号:
7887267 - 财政年份:2009
- 资助金额:
$ 15.65万 - 项目类别:
Early Autism Risk Longitudinal Investigation (EARLI) Network
早期自闭症风险纵向调查 (EARLI) 网络
- 批准号:
8053878 - 财政年份:2008
- 资助金额:
$ 15.65万 - 项目类别:
Early Autism Risk Longitudinal Investigation (EARLI) Network
早期自闭症风险纵向调查 (EARLI) 网络
- 批准号:
7277515 - 财政年份:2008
- 资助金额:
$ 15.65万 - 项目类别:
Early Autism Risk Longitudinal Investigation (EARLI) Network
早期自闭症风险纵向调查 (EARLI) 网络
- 批准号:
8073689 - 财政年份:2008
- 资助金额:
$ 15.65万 - 项目类别:
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