Early Autism Risk Longitudinal Investigation (EARLI) Network

早期自闭症风险纵向调查 (EARLI) 网络

• 批准号: 7277515
• 负责人: Craig J Newschaffer
• 金额: $ 274.3万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7277515
• 关键词: ADRB2 gene; Address; Age-Months; Agonist; Antibodies; Autistic Disorder; Autoimmunity; Award; Behavioral; Biological Markers; Blood specimen; California; Candidate Disease Gene; Catecholamines; Child; Child health care; Clinical assessments; Collection; Complex; Data; Data Collection; Data Coordinating Center; Diagnosis; Documentation; Epigenetic Process; Etiology; Evaluation; Exposure to; Gene Expression; Genes; Genetic; Genetic Polymorphism; Genotype; Goals; Grant; Home environment; House Dust; Institutes; Interview; Investigation; Laboratories; Life; Measurement; Measures; Mediating; Medical Records; Methods; Methylation; Mind; Molecular Profiling; Mothers; Natural History; Nature; Neonatal; Newborn Infant; Observational Study; Patient Self-Report; Pattern; Pediatric Hospitals; Perinatal; Perinatal Exposure; Phenotype; Philadelphia; Polychlorinated Biphenyls; Population Study; Predisposition; Pregnancy; Protocols documentation; Public Health Schools; Reporting; Research; Research Design; Research Personnel; Risk; Risk Factors; Risk Marker; Sample Size; Sampling; Series; Siblings; Site; Stress; Telephone Interviews; Third Pregnancy Trimester; Time; Universities; Visit; autism spectrum disorder; autoreactivity; behavior measurement; brain tissue; cohort; design; diaries; disorder risk; endophenotype; fetal; follow-up; gene environment interaction; in utero; maternal serum; pollutant; proband; programs; prospective; repository; urinary

DESCRIPTION (provided by applicant): The Early Autism Risk Longitudinal Investigation (EARLI) Network will establish and prospectively follow a cohort of mothers of children with an autism spectrum disorder (ASD) at the start of a subsequent pregnancy (with select preconception data collection). This enriched-risk cohort will have the potential to serve as a study population for a variety of observational studies on the etiology and natural history of ASDs. The Network includes an Administrative Center at the Drexel University School of Public Health, a Data Coordinating Center at University of California Davis, a Central Laboratory and Repository at the Johns Hopkins School of Public Health, and four field sites: 1) Drexel University School of Public Health / Children's Hospital of Philadelphia; 2) University of California Davis / MIND Institute; 3) Johns Hopkins University School of Public Health / Kennedy Krieger Institute; and 4) Northern California Kaiser Permanente. The EARLI Network will implement a core epidemiologic data collection protocol focusing on: 1) prospective documentation of exogenous exposure during pregnancy and early life; 2) collection and banking of biologic samples during pregnancy and early-life, allowing measurement of exposure biomarkers, endogenous risk biomarkers, genotypes, and gene-expression profiles; and 3) follow-up of the newborn sibling through 36 months of age to gather data on ASD diagnoses, continuous ASD behavioral domains, and other potential behavioral endophenotypes. The goal is to have data on 1,000 siblings of ASD probands from fetal life through 36 months of age. This will allow sufficiently-powered estimation of associations among exposures and biomarkers measured during the pre-, peri-, and neonatal periods and ASD risk as well as candidate gene, gene-environment interaction, epigenetic, and maternally-mediated genetic effects. Full data collection in the target sample size will require additional five-years beyond the initial award period; however, by the end of the award the Network will have followed 875 pregnancies and completed 250 24-month follow-up visits. The attached application describes a plan for establishing the cohort and presents a set of exemplary specific aims to be partially addressed during the initial award period and more completely addressed once data collection is completed. Other types of specific aims that could be addressed through additional analyses of EARLI Network cohort data are highlighted.

描述(由申请人提供)：早期自闭症风险纵向调查(EARLI)网络将建立并前瞻性地跟踪一组患有自闭症谱系障碍(ASD)儿童的母亲在下一次怀孕开始时的情况(通过精选的先入为主的数据收集)。这一风险增加的队列将有可能作为研究人群，对自闭症的病因学和自然病史进行各种观察性研究。该网络包括德雷克塞尔大学公共卫生学院的行政中心、加州大学戴维斯分校的数据协调中心、约翰霍普金斯大学公共卫生学院的中央实验室和资料库，以及四个现场站点：1)德雷克塞尔大学公共卫生学院/费城儿童医院；2)加州大学戴维斯分校/Mind研究所；3)约翰霍普金斯大学公共卫生学院/肯尼迪·克里格研究所；以及4)北加州凯撒永久医院。EARLI网络将实施核心流行病学数据收集协议，重点是：1)孕期和早期外源性暴露的预期文件；2)孕期和早期生物样本的收集和储存，允许测量暴露生物标记物、内源性风险生物标记物、基因类型和基因表达谱；以及3)对出生36个月的新生儿进行跟踪，以收集有关ASD诊断、持续ASD行为领域和其他潜在行为内表型的数据。其目标是获得1000名自闭症先证者从胎儿到36个月大的兄弟姐妹的数据。这将使我们能够充分评估在先期、围产期和新生儿期测量的暴露和生物标记物与ASD风险以及候选基因、基因-环境相互作用、表观遗传和母体介导的遗传效应之间的关联。按照目标样本量全面收集数据将需要在最初授权期之后再增加五年时间；然而，到授权期结束时，该网络将跟踪调查875例妊娠，完成250次为期24个月的后续访问。所附申请书描述了建立队列的计划，并提出了一套示范的具体目标，将在初始授权期内部分解决，并在数据收集完成后更全面地解决。还强调了可通过对EARLI网络队列数据进行额外分析来解决的其他类型的具体目标。