Early Autism Risk Longitudinal Investigation (EARLI) Network

早期自闭症风险纵向调查 (EARLI) 网络

• 批准号: 7277515
• 负责人: Craig J Newschaffer
• 金额: $ 274.3万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7277515
• 关键词: ADRB2 gene; Address; Age-Months; Agonist; Antibodies; Autistic Disorder; Autoimmunity; Award; Behavioral; Biological Markers; Blood specimen; California; Candidate Disease Gene; Catecholamines; Child; Child health care; Clinical assessments; Collection; Complex; Data; Data Collection; Data Coordinating Center; Diagnosis; Documentation; Epigenetic Process; Etiology; Evaluation; Exposure to; Gene Expression; Genes; Genetic; Genetic Polymorphism; Genotype; Goals; Grant; Home environment; House Dust; Institutes; Interview; Investigation; Laboratories; Life; Measurement; Measures; Mediating; Medical Records; Methods; Methylation; Mind; Molecular Profiling; Mothers; Natural History; Nature; Neonatal; Newborn Infant; Observational Study; Patient Self-Report; Pattern; Pediatric Hospitals; Perinatal; Perinatal Exposure; Phenotype; Philadelphia; Polychlorinated Biphenyls; Population Study; Predisposition; Pregnancy; Protocols documentation; Public Health Schools; Reporting; Research; Research Design; Research Personnel; Risk; Risk Factors; Risk Marker; Sample Size; Sampling; Series; Siblings; Site; Stress; Telephone Interviews; Third Pregnancy Trimester; Time; Universities; Visit; autism spectrum disorder; autoreactivity; behavior measurement; brain tissue; cohort; design; diaries; disorder risk; endophenotype; fetal; follow-up; gene environment interaction; in utero; maternal serum; pollutant; proband; programs; prospective; repository; urinary

DESCRIPTION (provided by applicant): The Early Autism Risk Longitudinal Investigation (EARLI) Network will establish and prospectively follow a cohort of mothers of children with an autism spectrum disorder (ASD) at the start of a subsequent pregnancy (with select preconception data collection). This enriched-risk cohort will have the potential to serve as a study population for a variety of observational studies on the etiology and natural history of ASDs. The Network includes an Administrative Center at the Drexel University School of Public Health, a Data Coordinating Center at University of California Davis, a Central Laboratory and Repository at the Johns Hopkins School of Public Health, and four field sites: 1) Drexel University School of Public Health / Children's Hospital of Philadelphia; 2) University of California Davis / MIND Institute; 3) Johns Hopkins University School of Public Health / Kennedy Krieger Institute; and 4) Northern California Kaiser Permanente. The EARLI Network will implement a core epidemiologic data collection protocol focusing on: 1) prospective documentation of exogenous exposure during pregnancy and early life; 2) collection and banking of biologic samples during pregnancy and early-life, allowing measurement of exposure biomarkers, endogenous risk biomarkers, genotypes, and gene-expression profiles; and 3) follow-up of the newborn sibling through 36 months of age to gather data on ASD diagnoses, continuous ASD behavioral domains, and other potential behavioral endophenotypes. The goal is to have data on 1,000 siblings of ASD probands from fetal life through 36 months of age. This will allow sufficiently-powered estimation of associations among exposures and biomarkers measured during the pre-, peri-, and neonatal periods and ASD risk as well as candidate gene, gene-environment interaction, epigenetic, and maternally-mediated genetic effects. Full data collection in the target sample size will require additional five-years beyond the initial award period; however, by the end of the award the Network will have followed 875 pregnancies and completed 250 24-month follow-up visits. The attached application describes a plan for establishing the cohort and presents a set of exemplary specific aims to be partially addressed during the initial award period and more completely addressed once data collection is completed. Other types of specific aims that could be addressed through additional analyses of EARLI Network cohort data are highlighted.

描述（由申请人提供）：早期自闭症风险纵向调查（EARLI）网络将在随后的怀孕开始时建立并前瞻性地跟踪自闭症谱系障碍（ASD）儿童的母亲队列（选择孕前数据收集）。 这个高风险队列将有可能作为一个研究人群的各种观察性研究的病因和ASD的自然史。 该网络包括德雷克塞尔大学公共卫生学院的一个行政中心、加州戴维斯大学的一个数据协调中心、约翰霍普金斯大学公共卫生学院的一个中央实验室和储存库，以及四个实地站点：1）德雷克塞尔大学公共卫生学院/费城儿童医院; 2）加州戴维斯大学/ MIND研究所; 3）约翰霍普金斯大学公共卫生学院/肯尼迪克里格研究所;以及4）北方加州凯撒医疗机构。 EARLI网络将实施一项核心流行病学数据收集协议，重点是：1）妊娠和生命早期外源性暴露的前瞻性文件; 2）妊娠和生命早期生物样本的收集和储存，允许测量暴露生物标志物、内源性风险生物标志物、基因型和基因表达谱;和3）随访新生儿兄弟姐妹直到36个月大，以收集关于ASD诊断、连续ASD行为域和其他潜在行为内表型的数据。 目标是获得1,000名ASD先证者兄弟姐妹从胎儿到36个月的数据。 这将允许对在产前、产中和新生儿期测量的暴露和生物标志物与ASD风险以及候选基因、基因-环境相互作用、表观遗传和母体介导的遗传效应之间的关联进行有效估计。 目标样本量的完整数据收集将需要在最初的奖励期之后再花五年时间;然而，到奖励结束时，该网络将跟踪875例妊娠，并完成250次24个月的随访。 所附申请描述了建立队列的计划，并提出了一套示范性的具体目标，在最初的授标期间将部分解决，一旦完成数据收集，将更全面地解决。 其他类型的具体目标，可以通过EARLI网络队列数据的额外分析来解决突出。