Early Autism Risk Longitudinal Investigation (EARLI) Network

早期自闭症风险纵向调查 (EARLI) 网络

• 批准号: 8053878
• 负责人: Craig J Newschaffer
• 金额: $ 286.44万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8053878
• 关键词: ADRB2 gene; Address; Age-Months; Agonist; Antibodies; Autistic Disorder; Autoimmunity; Award; Behavioral; Biological Markers; Blood specimen; California; Candidate Disease Gene; Catecholamines; Child; Clinical assessments; Collection; Complex; Data; Data Collection; Data Coordinating Center; Diagnosis; Documentation; Epigenetic Process; Etiology; Evaluation; Exposure to; First Pregnancy Trimester; Gene Expression; Genes; Genetic; Genetic Polymorphism; Genotype; Goals; Grant; Home environment; House Dust; Institutes; Interview; Investigation; Laboratories; Life; Measurement; Measures; Mediating; Medical Records; Methylation; Molecular Profiling; Mothers; Natural History; Nature; Neonatal; Newborn Infant; Observational Study; Patient Self-Report; Pattern; Pediatric Hospitals; Perinatal; Perinatal Exposure; Phenotype; Philadelphia; Polychlorinated Biphenyls; Population Study; Predisposition; Pregnancy; Protocols documentation; Public Health Schools; Reporting; Research; Research Design; Research Methodology; Research Personnel; Risk; Risk Factors; Risk Marker; Sample Size; Sampling; Series; Siblings; Site; Stress; Telephone Interviews; Third Pregnancy Trimester; Time; Umbilical Cord Blood; Universities; Visit; autism spectrum disorder; autoreactivity; behavior measurement; brain tissue; cohort; design; diaries; disorder risk; endophenotype; epidemiologic data; fetal; follow-up; gene environment interaction; high risk; in utero; maternal serum; pollutant; proband; programs; prospective; repository; urinary

DESCRIPTION (provided by applicant): The Early Autism Risk Longitudinal Investigation (EARLI) Network will establish and prospectively follow a cohort of mothers of children with an autism spectrum disorder (ASD) at the start of a subsequent pregnancy (with select preconception data collection). This enriched-risk cohort will have the potential to serve as a study population for a variety of observational studies on the etiology and natural history of ASDs. The Network includes an Administrative Center at the Drexel University School of Public Health, a Data Coordinating Center at University of California Davis, a Central Laboratory and Repository at the Johns Hopkins School of Public Health, and four field sites: 1) Drexel University School of Public Health / Children's Hospital of Philadelphia; 2) University of California Davis / MIND Institute; 3) Johns Hopkins University School of Public Health / Kennedy Krieger Institute; and 4) Northern California Kaiser Permanente. The EARLI Network will implement a core epidemiologic data collection protocol focusing on: 1) prospective documentation of exogenous exposure during pregnancy and early life; 2) collection and banking of biologic samples during pregnancy and early-life, allowing measurement of exposure biomarkers, endogenous risk biomarkers, genotypes, and gene-expression profiles; and 3) follow-up of the newborn sibling through 36 months of age to gather data on ASD diagnoses, continuous ASD behavioral domains, and other potential behavioral endophenotypes. The goal is to have data on 1,000 siblings of ASD probands from fetal life through 36 months of age. This will allow sufficiently-powered estimation of associations among exposures and biomarkers measured during the pre-, peri-, and neonatal periods and ASD risk as well as candidate gene, gene-environment interaction, epigenetic, and maternally-mediated genetic effects. Full data collection in the target sample size will require additional five-years beyond the initial award period; however, by the end of the award the Network will have followed 875 pregnancies and completed 250 24-month follow-up visits. The attached application describes a plan for establishing the cohort and presents a set of exemplary specific aims to be partially addressed during the initial award period and more completely addressed once data collection is completed. Other types of specific aims that could be addressed through additional analyses of EARLI Network cohort data are highlighted.

描述（由申请人提供）：早期自闭症风险纵向调查 (EARLI) 网络将在随后的怀孕开始时建立并前瞻性地跟踪一组患有自闭症谱系障碍 (ASD) 的儿童的母亲（并收集精选的孕前数据）。 这个高风险队列将有可能作为自闭症谱系障碍病因学和自然史的各种观察性研究的研究人群。 该网络包括德雷塞尔大学公共卫生学院的一个行政中心、加州大学戴维斯分校的一个数据协调中心、约翰霍普金斯大学公共卫生学院的一个中心实验室和存储库以及四个现场站点：1) 德雷塞尔大学公共卫生学院/费城儿童医院； 2）加州大学戴维斯分校/MIND研究所； 3）约翰霍普金斯大学公共卫生学院/肯尼迪克里格研究所； 4) 北加州凯撒医疗机构。 EARLI 网络将实施核心流行病学数据收集协议，重点关注：1）妊娠和早期生命期间外源性暴露的前瞻性记录； 2）在怀孕和生命早期收集和储存生物样本，以便测量暴露生物标志物、内源性风险生物标志物、基因型和基因表达谱； 3) 对新生儿兄弟姐妹进行随访直至 36 个月大，以收集有关 ASD 诊断、持续 ASD 行为领域和其他潜在行为内表型的数据。 目标是获得 1,000 名 ASD 先证者兄弟姐妹从胎儿期到 36 个月大的数据。 这将能够对孕前、围产期和新生儿期测量的暴露和生物标志物与 ASD 风险以及候选基因、基因-环境相互作用、表观遗传和母体介导的遗传效应之间的关联进行充分有力的估计。 目标样本量的完整数据收集将需要在初始奖励期之后额外五年；然而，到颁奖结束时，该网络将跟踪 875 例怀孕，并完成 250 次 24 个月的随访。 所附申请描述了建立队列的计划，并提出了一组示例性具体目标，这些目标将在初始奖励期间部分解决，并在数据收集完成后更全面地解决。 强调了可以通过对 EARLI 网络队列数据进行额外分析来解决的其他类型的具体目标。