Heart Disease, Inflammatory Markers and Particulates

心脏病、炎症标志物和颗粒物

• 批准号: 7055149
• 负责人: ROBIN PUETT
• 金额: $ 4.6万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7055149
• 关键词: air pollution; atherosclerosis; biomarker; body physical activity; cardiovascular disorder epidemiology; cardiovascular disorder risk; clinical research; diet; geographic site; human data; inflammation; information systems; lifestyle; mathematical model; myocardial infarction; obesity; postdoctoral investigator; smoking

DESCRIPTION (provided by applicant): Epidemiologic evidence supports an association between particulate air pollution and cardiovascular morbidity and mortality, however biological mechanisms for this relationship have not yet been elucidated. Recent research suggests that inflammatory markers are feasible indicators of cardiovascular outcomes and that exposure to particulate air pollution may elevate certain inflammatory markers. Using data from nested case-control studies of coronary heart disease (CHD) embedded in the Nurses' Health Study and the Health Professionals' Follow-up Study, we propose to examine the relationships among chronic particulate exposure, inflammatory markers and CHD. To obtain more accurate estimates of particulate exposure, a complex Geographic Information System (CIS) model will be applied. We will also use Structural Equation Models (SEM) to examine the complex interrelationships among particulate exposure, inflammatory markers and CHD. Hypothesis 1: Chronic particulate exposure increases inflammatory markers related to CHD. Specific Aims: Examine the association between inflammatory markers and chronic exposure to PM2.5 and PM10. Hypothesis 2: Chronic particulate exposure increases the risk of CHD. Specific Aims: Assess whether particulate exposures are elevated among persons with CHD and whether inflammatory markers modify the relationship between particulate exposure and CHD. Hypothesis 3: Inflammatory markers mediate the relationship between CHD and chronic particulate exposure. Specific Aims: Use SEM to examine the direct and indirect contribution of particulate exposure to CHD.

描述（由申请人提供）：流行病学证据支持颗粒空气污染与心血管发病率和死亡率之间的关联，但这种关系的生物学机制尚未阐明。最近的研究表明，炎症标志物是心血管结局的可行指标，暴露于颗粒空气污染可能会提高某些炎症标志物。利用护士健康研究和卫生专业人员随访研究中嵌套的冠心病病例对照研究的数据，我们建议研究慢性颗粒物暴露、炎症标志物和冠心病之间的关系。为了获得更准确的颗粒物暴露估计，将应用一个复杂的地理信息系统（CIS）模型。我们还将使用结构方程模型（SEM）来检查颗粒暴露，炎症标志物和冠心病之间的复杂相互关系。假设1：慢性颗粒物暴露增加与冠心病相关的炎症标志物。具体目的：研究炎症标志物与慢性暴露于PM2.5和PM10之间的关系。假设2：长期接触颗粒物会增加患冠心病的风险。具体目的：评估冠心病患者颗粒暴露是否升高，炎症标志物是否改变颗粒暴露与冠心病之间的关系。假设3：炎症标志物介导冠心病与慢性颗粒物暴露之间的关系。具体目的：利用扫描电镜研究暴露于微粒对冠心病的直接和间接影响。