THE BIOLOGIC EFFECTS OF ANDROGENS IN MEN AND WOMEN

描述(申请人提供)：德鲁大学在教育、卫生服务研究和社区服务方面有着长期的合作历史，是密西西比河以西唯一的黑人医学院，以及美国顶尖大学之一加州大学洛杉矶分校，具有战略地位，可以建立一个多学科、合作、专注于主题和综合的生殖科学研究项目，旨在研究雄激素对男性和女性的生物影响。德鲁-加州大学洛杉矶分校生殖科学研究中心将通过支持几个新的翻译和临床研究项目的开发，增强和加强德鲁大学教职员工和学员的研究基础设施和研究能力，这些项目被认为是高度优先和重要的项目，因为它们与男性和女性的生殖健康相关。这项拨款提案的目标--开发一个综合研究计划，为德鲁大学未来在生殖生物学、生殖内分泌学和生殖医学领域的扩展奠定基础--体现在以下具体目标中：1)。支持实施两个生殖科学研究项目，有效地利用我们机构的科学优势，并促进对本RFA确定的优先领域的具体研究主题采取多学科方法；2)为两个试点项目提供支持，以生成数据以促进创新假说和研究的发展，并支持我们的研究人员努力生成初步数据和出版物，以帮助确保向独立资助过渡；3)促进并正式确立德鲁大学和加州大学洛杉矶分校科学家之间新的生殖科学合作网络；4)建立行政和规划核心，以支持科学项目。这些具体目标将通过实施两个核心研究项目和两个试点项目来实现，每个项目都有与中心长期目标相一致的相互关联的具体目标。研究项目将得到行政和规划核心的支持。拟议的核心项目和试点项目通过一个共同的主题相互联系，即雄激素对男性和女性的生物影响。充满活力的项目领导力，与主题相关并从我们目前的优势逻辑演变而来的跨学科研究项目，双机构支持的热情承诺，大量有才华的参与教职员工，我们机构在少数族裔社区的深厚历史根基，以及来自先前存在的激素检测、身体成分、RCMI[少数民族机构研究中心]分子医学核心、运动生理学核心实验室和大学管理的强大基础设施支持，使我们的机构特别适合从NICHD计划中受益。

DESCRIPTION (provided by applicant): With a longstanding history of collaborations in education, health services research and community service, Drew University, the only historically black medical school west of the Mississippi River, and UCLA, one of this nation's premier universities, are strategically positioned to establish a multi-disciplinary, collaborative, thematically focused and integrated reproductive science research program aimed at studying the biologic effects of androgens in men and women. The Drew-UCLA Reproductive Science Research Center will augment and strengthen the research infrastructure and research capabilities of faculty and trainees at Drew University by supporting the development of several new translational and clinical research projects deemed to be of high priority and significance because of their relevance to reproductive health of men and women. The objectives of this grant proposal - to develop an integrated research program that serves as the foundation for future expansion in reproductive biology, reproductive endocrinology, and reproductive medicine at Drew - are reflected in the following specific aims: 1). Support the implementation of two reproductive science research projects that effectively use the scientific strengths of our institutions, and promote multi-disciplinary approaches to the specific research topics in the priority areas identified by this RFA; 2) Provide support for two pilot projects to generate data to facilitate the development of innovative hypotheses and studies, and support the efforts of our investigators to generate preliminary data and publications that can help assure their transition to independent funding; 3) Facilitate and formalize new collaborative networks in reproductive science between scientists at Drew University and UCLA; 4) Develop an Administrative and Planning Core to support the scientific projects. These specific aims will be accomplished by implementing two core research projects and two pilot projects, each having interrelated specific aims consistent with the Center's long-term objectives. The research projects will be supported by an Administrative and Planning Core. The proposed core and pilot projects are inter-linked by a common theme, namely, Biologic Effects of Androgens in Men and Women. Energetic program leadership, cross-disciplinary research projects that are thematically-linked and that evolve logically from our current strengths, enthusiastic commitment of bi-institutional support, a large pool of talented, participating faculty, deep historical roots of our institution in the minority communities, and strong infrastructural support from pre-existing Hormone Assay, Body Composition, RCMI [Research Center for Minority Institution] Molecular Medicine Core, and Exercise Physiology Core laboratories, and University administration, make our institution particularly suitable to benefit from this NICHD initiative.