Cortical Control Using Multiple Signal Modalities

描述(由申请人提供)：皮质控制正在成为神经假体研究的一个重要领域。作为控制信号被研究的不同类型的神经信号取决于采样的脑组织的体积和记录电极的侵入性。特别是，多通道神经元棘波记录和局部场电位已经被分别考虑用于实时皮质控制应用。虽然这些信号都是使用可植入微电极阵列同时记录的皮质内细胞外电位，但在提供优化的皮质控制的背景下，这些信号之间的关系尚未被探索。本项目的目标是研究在实时皮层控制范例中单独或协同使用的多通道棘波记录和局部场电位的信息内容。这种对棘波记录和局部场电位的控制方面的综合观察试图了解将这些信号组合在一起可以在多大程度上用于优化皮质控制信号。这个项目有两个具体目标。具体目标1旨在定量确定多通道局域场势和尖峰记录之间的共享信息。动物将被操作地调节，以仅调制多个局部场电位信号或仅调制多个尖峰记录，其中两种类型的信号都被记录。离线分析将调查有关目标状态的信息在这两种类型的信号之间和内部分布的程度。具体目标2旨在研究当受试者执行使用这两种信号的操作条件反射任务时，局部场电位和棘波记录的相对贡献。受试者将有机会同时使用(或任一种)局部场电位和整体棘波活动来执行行为任务。两个信号的相对解码滤波器将被比较以确定主题偏好。然后，为了研究任务难度和通道偏好之间的相互作用，任务难度将被改变。该项目研究了皮质内信号组合用于神经假体控制的新用途，并可能对未来临床神经假体的发展做出贡献。

DESCRIPTION (provided by applicant): Cortical control is emerging as an important area in neuroprosthetic research. The different types of neural signals that are being investigated as control signals depend on the volume of brain tissue that is sampled and the invasiveness of the recording electrode. In particular, multi-channel neuronal spike recordings and local field potentials have been separately considered for real-time cortical control applications. While these signals are both intracortical extracellular potentials that are recorded simultaneously using implantable microelectrode arrays, the relationship between these signals in the context of providing optimized cortical control has not yet been explored. The objective of this project is to investigate the information content of multi-channel spike recordings and local field potentials used either in isolation or in concert in a real-time cortical control paradigm. This integrated look at the control aspects of spike recordings and local field potentials seeks to understand the degree to which combining these signals can be used to optimize the cortical control signal. This project has two specific aims. Specific aim 1 is directed at quantitatively determining the shared information between multi-channel local field potentials and spike recordings. Animals will be operantly conditioned to modulate either multiple local field potential signals only or multiple spike recordings only, with both types of signals being recorded. Offline analysis will investigate the degree to which information about the target states is distributed between and within the two types of signals. Specific aim 2 is directed at investigating the relative contribution of local field potentials and spike recordings when subjects perform an operant conditioning task that utilizes both types of signals. Subjects will be provided the opportunity to use both (or either) local field potentials and ensemble spike activity to perform a behavioral task. The relative decoding filters for both signals will be compared to determine subject preference. Task difficulty will then be varied in order to study the interplay between task difficulty and modality preference. This project investigates a novel use of intracortical signal combinations for neuroprosthetic control and it is likely to contribute to the development of future clinical neuroprostheses.