Cortical Control Using Multiple Signal Modalities

描述（由申请人提供）：皮层控制正在成为神经假肢研究的一个重要领域。作为控制信号被研究的不同类型的神经信号取决于被采样的脑组织的体积和记录电极的侵入性。特别是，多通道神经元尖峰记录和局部场电位已被单独考虑用于实时皮质控制应用。虽然这些信号都是使用可植入微电极阵列同时记录的皮层内细胞外电位，但这些信号在提供优化皮层控制的背景下之间的关系尚未被探索。本项目的目的是研究多通道尖峰记录和局部场电位的信息内容，无论是单独使用还是在实时皮质控制范式中协同使用。通过对尖峰记录和局部场电位控制方面的综合研究，我们试图了解将这些信号结合起来用于优化皮质控制信号的程度。这个项目有两个具体目标。具体目标1是针对定量确定多通道局部场电位和尖峰记录之间的共享信息。动物将被训练成只调制多个局部场电位信号或只调制多个尖峰记录，两种类型的信号都被记录下来。离线分析将调查关于目标状态的信息在两种类型的信号之间和内部分布的程度。具体目标2是针对研究局部场电位和峰值记录的相对贡献，当受试者执行操作性条件反射任务时，利用这两种类型的信号。受试者将有机会同时（或其中一种）使用局部场电位和整体脉冲活动来执行行为任务。将比较两个信号的相对解码滤波器以确定主题偏好。为了研究任务难度和模态偏好之间的相互作用，任务难度将被改变。本项目研究了皮质内信号组合用于神经假体控制的新用途，这可能有助于未来临床神经假体的发展。

DESCRIPTION (provided by applicant): Cortical control is emerging as an important area in neuroprosthetic research. The different types of neural signals that are being investigated as control signals depend on the volume of brain tissue that is sampled and the invasiveness of the recording electrode. In particular, multi-channel neuronal spike recordings and local field potentials have been separately considered for real-time cortical control applications. While these signals are both intracortical extracellular potentials that are recorded simultaneously using implantable microelectrode arrays, the relationship between these signals in the context of providing optimized cortical control has not yet been explored. The objective of this project is to investigate the information content of multi-channel spike recordings and local field potentials used either in isolation or in concert in a real-time cortical control paradigm. This integrated look at the control aspects of spike recordings and local field potentials seeks to understand the degree to which combining these signals can be used to optimize the cortical control signal. This project has two specific aims. Specific aim 1 is directed at quantitatively determining the shared information between multi-channel local field potentials and spike recordings. Animals will be operantly conditioned to modulate either multiple local field potential signals only or multiple spike recordings only, with both types of signals being recorded. Offline analysis will investigate the degree to which information about the target states is distributed between and within the two types of signals. Specific aim 2 is directed at investigating the relative contribution of local field potentials and spike recordings when subjects perform an operant conditioning task that utilizes both types of signals. Subjects will be provided the opportunity to use both (or either) local field potentials and ensemble spike activity to perform a behavioral task. The relative decoding filters for both signals will be compared to determine subject preference. Task difficulty will then be varied in order to study the interplay between task difficulty and modality preference. This project investigates a novel use of intracortical signal combinations for neuroprosthetic control and it is likely to contribute to the development of future clinical neuroprostheses.