Cortical Control Using Multiple Signal Modalities

描述（由申请人提供）：皮质控制正在成为神经假体研究的一个重要领域。 作为控制信号被研究的不同类型的神经信号取决于被采样的脑组织的体积和记录电极的侵入性。 特别是，多通道神经元尖峰记录和局部场电位已被分别考虑用于实时皮层控制应用。 虽然这些信号都是皮质内的细胞外电位，同时记录使用植入式微电极阵列，这些信号之间的关系，在提供优化的皮质控制的背景下尚未被探讨。 本项目的目的是调查的信息内容的多通道尖峰记录和局部场电位使用隔离或在音乐会中的实时皮层控制范例。 这种对尖峰记录和局部场电位的控制方面的综合研究旨在理解组合这些信号可以用于优化皮层控制信号的程度。 该项目有两个具体目标。 具体目标1是针对定量确定多通道局部场电位和锋电位记录之间的共享信息。 将对动物进行操作性条件反射，以仅调制多个局部场电位信号或仅调制多个尖峰记录，记录两种类型的信号。 离线分析将调查关于目标状态的信息在两种类型的信号之间和内部分布的程度。 具体目标2是针对调查的相对贡献的局部场电位和尖峰记录时，受试者执行操作性条件反射任务，利用这两种类型的信号。 受试者将有机会使用局部场电位和整体尖峰活动来执行行为任务。 将比较两个信号的相对解码滤波器以确定受试者偏好。 任务难度将被改变，以研究任务难度和通道偏好之间的相互作用。 该项目研究了一种新的使用皮质内信号组合的神经假体控制，它可能有助于未来的临床神经假体的发展。

DESCRIPTION (provided by applicant): Cortical control is emerging as an important area in neuroprosthetic research. The different types of neural signals that are being investigated as control signals depend on the volume of brain tissue that is sampled and the invasiveness of the recording electrode. In particular, multi-channel neuronal spike recordings and local field potentials have been separately considered for real-time cortical control applications. While these signals are both intracortical extracellular potentials that are recorded simultaneously using implantable microelectrode arrays, the relationship between these signals in the context of providing optimized cortical control has not yet been explored. The objective of this project is to investigate the information content of multi-channel spike recordings and local field potentials used either in isolation or in concert in a real-time cortical control paradigm. This integrated look at the control aspects of spike recordings and local field potentials seeks to understand the degree to which combining these signals can be used to optimize the cortical control signal. This project has two specific aims. Specific aim 1 is directed at quantitatively determining the shared information between multi-channel local field potentials and spike recordings. Animals will be operantly conditioned to modulate either multiple local field potential signals only or multiple spike recordings only, with both types of signals being recorded. Offline analysis will investigate the degree to which information about the target states is distributed between and within the two types of signals. Specific aim 2 is directed at investigating the relative contribution of local field potentials and spike recordings when subjects perform an operant conditioning task that utilizes both types of signals. Subjects will be provided the opportunity to use both (or either) local field potentials and ensemble spike activity to perform a behavioral task. The relative decoding filters for both signals will be compared to determine subject preference. Task difficulty will then be varied in order to study the interplay between task difficulty and modality preference. This project investigates a novel use of intracortical signal combinations for neuroprosthetic control and it is likely to contribute to the development of future clinical neuroprostheses.