Fungal determinants and host cell death signals in fatal Candida infections

致命念珠菌感染中的真菌决定因素和宿主细胞死亡信号

• 批准号: nhmrc : 1081072
• 负责人: A/Pr Ana Traven
• 金额: $ 43.61万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/fungal-determinants-host-candida-infections/518784
• 关键词: Fungal; determinants; host; cell; death

Fungal pathogens are a major burden in hospital settings as they evade the immune system and cause lethal sepsis. This project will determine the molecular factors utilized by the fungal pathogen Candida to kill host immune cells. We will investigate whether immune cell death contributes to the high fatality rate, commonly associated with systemic Candida infections, and whether this can be targeted by novel therapeutics.

真菌病原体是医院环境中的主要负担，因为它们逃避免疫系统并导致致命的败血症。本项目将确定真菌病原体念珠菌用于杀死宿主免疫细胞的分子因子。我们将研究免疫细胞死亡是否有助于高病死率，通常与系统性念珠菌感染有关，以及这是否可以通过新的治疗方法来靶向。