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Fungal determinants and host cell death signals in fatal Candida infections

Fungal determinants and host cell death signals in fatal Candida infections
致命念珠菌感染中的真菌决定因素和宿主细胞死亡信号
批准号:
nhmrc : 1081072
负责人:
A/Pr Ana Traven
金额:
$43.61万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31

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中文摘要
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英文摘要
Fungal pathogens are a major burden in hospital settings as they evade the immune system and cause lethal sepsis. This project will determine the molecular factors utilized by the fungal pathogen Candida to kill host immune cells. We will investigate whether immune cell death contributes to the high fatality rate, commonly associated with systemic Candida infections, and whether this can be targeted by novel therapeutics.
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