An investigation into mitochondrial dynamics in the human pathogen Candida albicans

人类病原体白色念珠菌线粒体动力学的研究

• 批准号: nhmrc : 1101562
• 负责人: A/Pr Ana Traven
• 金额: $ 39.89万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/an-investigation-mitochondrial-candida-albicans/662556
• 关键词: investigation; into; mitochondrial; dynamics; human

Our goal is to find new therapies to treat infections with Candida albicans, a major human pathogen that causes highly fatal hospital-associated disease. We have identified the mitochondrion, the cellular powerhouse, as a promising target for the development of new anti-candida drugs. We will use innovative imaging and molecular approaches, together with experimental animal infection models to understand how mitochondria could be inhibited to treat life-threatening infections with Candida.

我们的目标是找到治疗白色念珠菌感染的新疗法，白色念珠菌是一种主要的人类病原体，可导致高度致命的医院相关疾病。我们已经确定了细胞发电站-我们将使用创新的成像和分子方法，以及实验动物感染模型，以了解如何抑制线粒体来治疗威胁生命的念珠菌感染。