Understanding the mechanisms of GABA type-A receptor activation and drug modulation
Understanding the mechanisms of GABA type-A receptor activation and drug modulation
批准号:
DP120104373
负责人:
Prof Joseph Lynch
金额:
$20.42万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2014-12-31
中文摘要
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英文摘要
There is currently little understanding of how sedative and anxiolytic drugs, including valium, interact with their receptors in the brain. This project will dramatically increase our understanding of how these receptors work and how drugs affect their activity. This will provide new insights into drug discovery and design.
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会议论文
The Effects of Human Epilepsy Mutations on Synaptic GABA-A Receptors Studied by Localization-based Superresolution Microscopy
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批准号:nhmrc : 1147600
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项目类别:Project Grants
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资助金额:$34.95万
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财政年份:2018
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负责人:Prof Joseph Lynch
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依托单位:
The alpha5 GABA-A receptor: delineating an emerging therapeutic target
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批准号:nhmrc : GNT1120947
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项目类别:Project Grants
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资助金额:$48.12万
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财政年份:2017
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负责人:Prof Joseph Lynch
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依托单位:
The alpha5 GABA-A receptor: delineating an emerging therapeutic target
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批准号:nhmrc : 1120947
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项目类别:Project Grants
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资助金额:$32.84万
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财政年份:2017
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负责人:Prof Joseph Lynch
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依托单位:
The role of zinc in synaptic transmission in the central nervous system
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批准号:DP150102428
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项目类别:Discovery Projects
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资助金额:$25.52万
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财政年份:2015
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负责人:Prof Joseph Lynch
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依托单位:
A novel mechanism for therapeutically modulating neurotransmitter-activated ion channels
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批准号:nhmrc : 1060707
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项目类别:Project Grants
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资助金额:$44.51万
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财政年份:2014
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负责人:Prof Joseph Lynch
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依托单位:
Finding new ways to treat pain and anxiety disorders
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批准号:nhmrc : GNT1058542
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项目类别:Research Fellowships
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资助金额:$72.76万
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财政年份:2014
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负责人:Prof Joseph Lynch
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依托单位:
Inhibitory neurotransmitter receptors as therapeutic targets for chronic pain and anxiety disorders
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批准号:nhmrc : 1058542
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项目类别:Research Fellowships
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资助金额:$50.9万
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财政年份:2014
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负责人:Prof Joseph Lynch
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依托单位:
Inhibitory receptors in the amygdala
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批准号:nhmrc : GNT1062183
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项目类别:Project Grants
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资助金额:$71.19万
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财政年份:2014
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负责人:Prof Joseph Lynch
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依托单位:
Function and physiological role of inhibitory circuits in the amygdala
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批准号:nhmrc : 1062183
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项目类别:Project Grants
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资助金额:$49.44万
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财政年份:2014
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负责人:Prof Joseph Lynch
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依托单位:
The molecular basis of ionic selectivity in nicotinic-type ion channel receptors
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批准号:DP130101702
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项目类别:Discovery Projects
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资助金额:$24.87万
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财政年份:2013
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负责人:Prof Joseph Lynch
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依托单位:
New tools to activate and silence neural circuits
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批准号:LP120100297
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项目类别:Linkage Projects
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资助金额:$32.92万
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财政年份:2012
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负责人:Prof Joseph Lynch
-
依托单位:
Developing novel selective glycine receptor potentiators as a means to control pain.
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批准号:nhmrc : 631448
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项目类别:NHMRC Project Grants
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资助金额:$36.85万
-
财政年份:2010
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负责人:Prof Joseph Lynch
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依托单位:
Activation mechanisms of Cys-loop ion channel receptors
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批准号:DP1092582
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项目类别:Discovery Projects
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资助金额:$24.24万
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财政年份:2010
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负责人:Prof Joseph Lynch
-
依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 569570
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项目类别:NHMRC Research Fellowships
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资助金额:$42.79万
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财政年份:2009
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负责人:Prof Joseph Lynch
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依托单位:
Identification of novel therapeutic binding sites on glycine receptors by high throughput screening
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批准号:nhmrc : 511169
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项目类别:NHMRC Project Grants
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资助金额:$36.14万
-
财政年份:2008
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负责人:Prof Joseph Lynch
-
依托单位:
Therapeutic potential of glycine receptors in pain sensory pathways
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批准号:nhmrc : 455931
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项目类别:NHMRC Project Grants
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资助金额:$19.49万
-
财政年份:2007
-
负责人:Prof Joseph Lynch
-
依托单位:
Molecular structure and function of the glycine receptor
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批准号:DP0773954
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项目类别:Discovery Projects
-
资助金额:$18.25万
-
财政年份:2007
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负责人:Prof Joseph Lynch
-
依托单位:
Subunit stoichiometry and arrangement in the glycine receptor
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批准号:DP0451836
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项目类别:Discovery Projects
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资助金额:$16.71万
-
财政年份:2004
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负责人:Prof Joseph Lynch
-
依托单位:
Tropisetron: molecular mechanisms of action at the 5-HT3 receptor and the glycine receptor
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批准号:nhmrc : 301053
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项目类别:NHMRC Project Grants
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资助金额:$24.79万
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财政年份:2004
-
负责人:Prof Joseph Lynch
-
依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 301023
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项目类别:NHMRC Research Fellowships
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资助金额:$38.92万
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财政年份:2004
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负责人:Prof Joseph Lynch
-
依托单位:
国内基金
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