Compact Multi-Wavelength Probe for Quantitative Tissue *

描述（由申请人提供）： 在650- 1000 nm波长范围内的定量近红外组织光谱是用于测量组织光学特性并将它们与组织成分（诸如水、脂质、氧合血红蛋白和脱氧血红蛋白）相关联的灵敏的非侵入性工具。特别是，使用频域和稳态宽带测量提供了相当大的承诺，在检测，表征和治疗监测乳腺癌。然而，目前，获得准确的光谱信息需要多个分立的二极管激光器和一个白色光源，用于在单个光源和检测器位置处进行测量。这需要复杂且耗电的系统，对于空间变化的多点测量具有增加的复杂性。 本研究旨在建立一个单芯片多波长源，可以取代分立二极管激光器和白色光源。该光源采用晶圆键合技术，以创建单片16通道多波长阵列。结合温度调谐，该源可以覆盖整个650- 1000 nm光谱，并用于频域和稳态测量。阶段！将证明4通道阵列的可行性。第二阶段将扩展到完整的波长覆盖范围，优化功率，并将新的光源纳入功能光谱探针，该探针将在组织模型，动物模型和人类受试者中进行评估。

DESCRIPTION (provided by applicant): Quantitative near infrared tissue spectroscopy in the 650-1000nm wavelength range is a sensitive non-invasive tool for measuring tissue optical properties, and correlating them with tissue components such as water, lipids, oxy-hemoglobin, and deoxy-hemoglobin. In particular, the use of both frequency domain and steady state broadband measurements offers considerable promise in the detection, characterization, and therapeutic monitoring of breast cancer. Currently, however, obtaining accurate spectral information requires multiple discrete diode lasers and a white light source for measurements at a single source and detector position. This requires a complex and power consumptive system, with increasing complexity for multi-point measurements of spatial variation. This research seeks to create a single-chip multi-wavelength source that can replace both discrete diode lasers and white light sources. The proposed source employs wafer bonding technology to create monolithic 16-channel multi-wavelength arrays. In conjunction with temperature tuning, this source can cover the entire 650-1000nm spectrum, and be used for both frequency domain and steady state measurements. Phase ! will demonstrate feasibility with a 4 channel array. Phase II will extend to complete wavelength coverage, optimize power, and incorporate the new source into a functional spectroscopic probe which will be evaluated in tissue phantoms, animal models, and human subjects.