Ultrahigh speed and resolution OCT/OCM using broadband swept VCSEL technology

使用宽带扫频 VCSEL 技术的超高速和分辨率 OCT/OCM

• 批准号: 8330339
• 负责人: Vijaysekhar Jayaraman
• 金额: $ 38.2万
• 依托单位: PRAEVIUM RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8330339
• 关键词: Amplifiers; Area; Back; Biopsy; Boston; Clinical; Clinical Research; Collaborations; Computers; Data; Detection; Development; Diagnostic; Digital Signal Processing; Elements; Endoscopes; Engineering; Equilibrium; Evaluation; Excision; Excision biopsy; Fiber Optics; Financial compensation; Frequencies; Funding; Future; Gastrointestinal tract structure; Generations; Goals; Gold; Grant; Histology; Histopathology; Image; Imagery; Imaging technology; Institutes; Investments; Israel; Laboratories; Laparoscopes; Lasers; Legal patent; Light; Manufacturer Name; Marketing; Massachusetts; Measures; Medical; Medical center; Microscope; Microscopy; Morphology; Optical Coherence Tomography; Optics; Pathology; Performance; Process; Public Health; Research; Resolution; Risk; Scanning; Screening for cancer; Semiconductors; Series; Source; Specimen Handling; Speed; Staining method; Stains; Structure; Surface; System; Systems Development; Technology; Three-Dimensional Image; Three-Dimensional Imaging; Time; Tissues; Ultrasonography; Work; base; cancer imaging; cancer therapy; clinical application; commercialization; cost; imaging modality; improved; in vivo; instrument; laptop; medical schools; new technology; next generation; sample fixation; sound; tool; treatment response

The ultimate goal of this effort is to develop, validate, and commercialize an ultra-broad tuning range, ultrahigh scan rate, swept laser source imaging engine that will enable the next generation of Optical Coherence Tomography / Optical Coherence Microscopy (OCT/OCM) systems. OCT and OCM enable 3D in vivo volumetric imaging of tissue pathology by detecting the echo time delay of back-reflected and backscattered light. OCT and OCM have powerful advantages as a cancer imaging modality because they provide information on tissue pathology in real time, without the need to excise and process specimens as in conventional excisional biopsy and histopathology. OCT has an axial image resolution of ~5-10 um and can image tissue over a much wider area than possible using conventional pinch biopsy. In endoscopic OCT, imaging can be performed over several square centimeters of the lumen. OCM has transverse resolutions of 1-2 um and can provide 3D image information at the cellular level. Swept source / Fourier domain OCT/OCM using compact VCSEL (vertical cavity surface emitting lasers) promises to enable imaging with significantly higher imaging speeds than existing commercial OCT technology. We propose to develop a swept source imaging engine which achieves an axial scan rate of 1 MHz, ~40x faster than commercial ophthalmic OCT instruments (25 kHz axial scan rate). Furthermore, swept source OCT/OCM using VCSEL technologies can be engineered into a compact imaging engine which is smaller than a laptop computer. The development of a high performance OCT/OCM imaging engine for the OEM market will enable access to the technology by a wide range of both established and start-up medical companies. This development strategy, which contrasts with focusing on commercialization for a single clinical application, reduces risks and will accelerate the development and impact of the technology across a broad range of clinical applications for cancer imaging. This proposed effort builds upon advances in semiconductor materials technology and tunable lasers developed by Praevium Research, Inc. in NCI grant 4R44CA101067 and follow-on commercial investment by commercial partner, Thorlabs, Inc., the world's largest manufacturer of research OCT technology. This work involves a collaboration between the primary organization Praevium Reseach, Inc. commercial partner Thorlabs, and the OCT group at the Massachusetts Institute of Technology, who was responsible for the invention and development of OCT.

这项工作的最终目标是开发、验证和商业化超宽调谐范围， 扫描速率快，扫描激光源成像引擎，将使下一代光学 相干断层扫描/光学相干显微镜（OCT/OCM）系统。OCT和OCM支持3D 通过检测背向反射的回波时间延迟和 反向散射光OCT和OCM作为癌症成像方式具有强大的优势，因为它们 提供真实的组织病理学信息，而不需要切除和处理标本， 在常规切除活检和组织病理学中。OCT具有约5-10 μ m的轴向图像分辨率， 可以在比使用常规夹取活检可能的更宽的区域上对组织进行成像。在内镜 OCT成像可以在几平方厘米的管腔上进行。OCM具有横向 分辨率为1-2 μ m，并且可以提供细胞水平的3D图像信息。 使用紧凑型VCSEL（垂直腔面发射）的扫频源/傅立叶域OCT/OCM 激光器）有望实现比现有商业OCT显著更高成像速度的成像 技术.我们建议开发一种扫频源成像引擎，其轴向扫描速率达到1 MHz，比商用眼科OCT仪器快约40倍（25 kHz轴向扫描速率）。此外，委员会认为， 使用VCSEL技术的扫频源OCT/OCM可以被设计成紧凑的成像引擎 比笔记本电脑还小高性能OCT/OCM成像系统的研制 发动机的OEM市场将使获得技术的范围广泛，既建立和 初创医疗公司。这一发展战略与侧重于 单一临床应用的商业化，降低了风险，并将加速开发和 该技术对癌症成像广泛临床应用的影响。 这项提议的努力建立在半导体材料技术和可调谐激光器的进步之上 由Praevium Research，Inc.开发。在NCI赠款4 R44 CA 101067和后续商业投资中 由商业合作伙伴Thorlabs，Inc.全球最大的OCT技术研究制造商。这 工作涉及主要组织Praevium Reseach，Inc.商业 他的合伙人Thorlabs和马萨诸塞州理工学院的OCT小组， 为OCT的发明和发展做出了贡献。

项目成果

Correction of circumferential and longitudinal motion distortion in high-speed catheter/endoscope-based optical coherence tomography.

基于高速导管/内窥镜的光学相干断层扫描中圆周和纵向运动畸变的校正。

• DOI: 10.1364/boe.409074
• 发表时间: 2021
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Nguyen,TanHuu;Ahsen,OsmanOguz;Liang,Kaicheng;Zhang,Jason;Mashimo,Hiroshi;Fujimoto,JamesG
• 通讯作者: Fujimoto,JamesG

Rapidly swept, ultra-widely-tunable 1060 nm MEMS-VCSELs.

• DOI: 10.1049/el.2012.3180
• 发表时间: 2012-10-11
• 期刊: Electronics letters
• 影响因子: 1.1
• 作者: Jayaraman V;Cole GD;Robertson M;Burgner C;John D;Uddin A;Cable A
• 通讯作者: Cable A

High-sweep-rate 1310 nm MEMS-VCSEL with 150 nm continuous tuning range.

• DOI: 10.1049/el.2012.1552
• 发表时间: 2012-07-05
• 期刊: Electronics letters
• 影响因子: 1.1
• 作者: Jayaraman V;Cole GD;Robertson M;Uddin A;Cable A
• 通讯作者: Cable A