Ultrahigh speed and resolution OCT/OCM using broadband swept VCSEL technology

使用宽带扫频 VCSEL 技术的超高速和分辨率 OCT/OCM

• 批准号: 8038017
• 负责人: Vijaysekhar Jayaraman
• 金额: $ 39.99万
• 依托单位: PRAEVIUM RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8038017
• 关键词: Amplifiers; Area; Back; Biopsy; Boston; Clinical; Clinical Research; Collaborations; Computer Systems Development; Computers; Data; Detection; Development; Diagnostic; Digital Signal Processing; Elements; Endoscopes; Engineering; Equilibrium; Evaluation; Excision; Excision biopsy; Fiber Optics; Financial compensation; Frequencies; Funding; Future; Gastrointestinal tract structure; Generations; Goals; Gold; Grant; Histology; Histopathology; Image; Imagery; Imaging technology; Institutes; Investments; Israel; Laboratories; Laparoscopes; Lasers; Legal patent; Light; Manufacturer Name; Marketing; Massachusetts; Measures; Medical; Medical center; Microscope; Microscopy; Morphology; Optical Coherence Tomography; Optics; Pathology; Performance; Process; Public Health; Research; Resolution; Risk; Scanning; Screening for cancer; Semiconductors; Series; Source; Specimen Handling; Speed; Staining method; Stains; Structure; Surface; System; Technology; Three-Dimensional Image; Three-Dimensional Imaging; Time; Tissues; Ultrasonography; Work; base; cancer imaging; clinical application; commercialization; cost; imaging modality; improved; in vivo; instrument; laptop; medical schools; new technology; next generation; sample fixation; sound; tool; treatment response

DESCRIPTION (provided by applicant): The ultimate goal of this effort is to develop, validate, and commercialize an ultra-broad tuning range, ultrahigh scan rate, swept laser source imaging engine that will enable the next generation of Optical Coherence Tomography / Optical Coherence Microscopy (OCT/OCM) systems. OCT and OCM enable 3D in vivo volumetric imaging of tissue pathology by detecting the echo time delay of back-reflected and backscattered light. OCT and OCM have powerful advantages as a cancer imaging modality because they provide information on tissue pathology in real time, without the need to excise and process specimens as in conventional excisional biopsy and histopathology. OCT has an axial image resolution of ~5-10 um and can image tissue over a much wider area than possible using conventional pinch biopsy. In endoscopic OCT, imaging can be performed over several square centimeters of the lumen. OCM has transverse resolutions of 1-2 um and can provide 3D image information at the cellular level. Swept source / Fourier domain OCT/OCM using compact VCSEL (vertical cavity surface emitting lasers) promises to enable imaging with significantly higher imaging speeds than existing commercial OCT technology. We propose to develop a swept source imaging engine which achieves an axial scan rate of 1 MHz, ~40x faster than commercial ophthalmic OCT instruments (25 kHz axial scan rate). Furthermore, swept source OCT/OCM using VCSEL technologies can be engineered into a compact imaging engine which is smaller than a laptop computer. The development of a high performance OCT/OCM imaging engine for the OEM market will enable access to the technology by a wide range of both established and start-up medical companies. This development strategy, which contrasts with focusing on commercialization for a single clinical application, reduces risks and will accelerate the development and impact of the technology across a broad range of clinical applications for cancer imaging. This proposed effort builds upon advances in semiconductor materials technology and tunable lasers developed by Praevium Research, Inc. in NCI grant 4R44CA101067 and follow-on commercial investment by commercial partner, Thorlabs, Inc., the world's largest manufacturer of research OCT technology. This work involves a collaboration between the primary organization Praevium Reseach, Inc. commercial partner Thorlabs, and the OCT group at the Massachusetts Institute of Technology, who was responsible for the invention and development of OCT. PUBLIC HEALTH RELEVANCE: This effort is expected impact public health by advancing a new clinical tool capable of three dimensional in-vivo volumetric imaging of tissue pathology without the need for tissue excision and processing as in conventional excisional biopsy and histopathology. This tool employs advanced high resolution, high data rate optical coherence tomography (OCT), which measures backscattered echoes of reflected light, in the same way that ultrasound imaging measures sound echoes, but with an imaging resolution 10-100 higher than ultrasound. The proposed instrument operates at 40X the imaging speed of existing commercial OCT instruments, and is enabled by a new compact rapidly swept laser source.

描述（由申请人提供）：这项工作的最终目标是开发，验证和商业化超宽调谐范围，超高扫描速率，扫描激光源成像引擎，这将使下一代光学相干断层扫描/光学相干显微镜（OCT/OCM）系统成为可能。OCT和OCM通过检测背反射光和背散射光的回波时间延迟，实现了组织病理的三维体内体积成像。OCT和OCM作为一种癌症成像方式具有强大的优势，因为它们可以实时提供组织病理信息，而不需要像传统的切除活检和组织病理学那样切除和处理标本。OCT具有~5-10微米的轴向图像分辨率，并且可以在比传统的夹取活检更广泛的区域上成像组织。在内窥镜OCT中，可以在几平方厘米的腔内进行成像。OCM具有1-2微米的横向分辨率，可以提供细胞水平的三维图像信息。扫描源/傅里叶域OCT/OCM使用紧凑的VCSEL（垂直腔面发射激光器）有望实现比现有商用OCT技术更高的成像速度。我们建议开发一种扫描源成像引擎，其轴向扫描速率为1 MHz，比商用眼科OCT仪器（轴向扫描速率为25 kHz）快40倍。此外，使用VCSEL技术的扫描源OCT/OCM可以设计成比笔记本电脑更小的紧凑型成像引擎。针对OEM市场的高性能OCT/OCM成像引擎的开发将使广泛的成熟和初创医疗公司能够使用该技术。与专注于单一临床应用的商业化相比，这一发展战略降低了风险，并将加速该技术在广泛的癌症成像临床应用中的发展和影响。这项提议的努力建立在半导体材料技术和可调谐激光器的进步基础上，由Praevium Research， Inc.开发，NCI授予4R44CA101067，并由商业合作伙伴Thorlabs， Inc.（世界上最大的研究OCT技术制造商）进行后续商业投资。这项工作涉及主要组织Praevium research， Inc.的商业合作伙伴Thorlabs与麻省理工学院的OCT小组之间的合作，后者负责OCT的发明和开发。