Self-help Smokeless Tobacco Cessation for Young Users

青少年自助无烟戒烟

• 批准号: 7123060
• 负责人: JAMI L. OBERMAYER
• 金额: $ 59.29万
• 依托单位: PERSONAL IMPROVEMENT COMPUTER SYSTEMS
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-11-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7123060
• 关键词: adolescence (12-20); behavioral /social science research tag; clinical research; computer program /software; computers; human subject; human therapy evaluation; mathematics; patient oriented research; portable biomedical equipment; self help; smokeless tobacco; smoking cessation; technology /technique development; young adult human (21-34)

DESCRIPTION (provided by applicant): The purpose of this Phase II project is to further develop and evaluate the efficacy of a computerized self-help cessation intervention for adolescent and young adult smokeless tobacco (ST) users. The program utilizes a small handheld computer to deliver a scheduled gradual reduction of the frequency and duration of dips or chews until cessation is achieved. In Phase I, the feasibility of the program was tested with 30 smokeless tobacco users age 16 to 23 who utilized the program over a six week period. At the end of treatment, 20% of the intent to treat sample and 33% of the treatment completers were continuously abstinent and met 7-day point prevalence abstinence confirmed by saliva cotinine analysis. Those who failed to quit reduced their ST use by 53%. Subjects rated the program positively, but noted that delivery of the program on the prototyping research units used for the study were difficult to carry and hard to use regularly. For Phase II, the program algorithms will be further refined based on Phase I feedback and the program will be ported to a newly developed special purpose device (QuitKey) which is about the size of a keychain FOB and easy to carry. In addition, a snuff can lid holder will be engineered to allow the user to carry the device with their snuff can, thereby further improving ease of use and compliance. The Phase II program will then be evaluated in a multi-site trial of 350 adolescent and young adult ST users. Subjects will be randomly assigned to receive either a manual self-help program (Enough Snuff) or the QuitKey for Dippers and Chewers (QuitKey DC). ST use and related variables will be assessed at baseline and at 8 and 26 weeks post treatment initiation. The results of the study will provide data on the relative efficacy of these two minimal contacts, self-help treatments for adolescent and young adult ST users, and will determine if the proposed product is a viable cessation option for young ST users for whom few effective cessation options are available. By intervening early in the drug use trajectory of ST users, cessation can be achieved before long-term physical dependence and negative health effects develop.

描述（由申请人提供）：该第二阶段项目的目的是进一步开发和评估青少年和年轻成人无烟烟草（ST）使用者的计算机自助戒烟干预的有效性。该计划利用一台小型手持电脑，按计划逐步减少蘸食或咀嚼的频率和持续时间，直至达到戒烟目的。在第一阶段，该计划的可行性进行了测试，30名年龄在16至23岁的无烟烟草使用者谁利用该计划超过六个星期的时间。在治疗结束时，20%的意向治疗样本和33%的治疗完成者持续戒烟，并通过唾液可替宁分析证实了7天时间点戒烟率。那些未能戒烟的人减少了53%的ST使用。受试者积极评价该计划，但指出，交付的原型研究单位用于研究的程序是难以携带和难以经常使用。在第二阶段，将根据第一阶段的反馈进一步完善程序算法，并将程序移植到新开发的专用设备（QuitKey）上，该设备的大小与钥匙链FOB差不多，便于携带。此外，鼻烟壶盖保持器将被设计成允许用户携带具有鼻烟壶的装置，从而进一步提高易用性和顺应性。然后，将在350名青少年和年轻成人ST使用者的多中心试验中对II期计划进行评估。受试者将被随机分配接受手动自助程序（Enough Snuff）或用于Dippers和Chewers的QuitKey（QuitKey DC）。将在基线和治疗开始后8周和26周评估ST使用和相关变量。研究结果将提供这两种最小接触、自助治疗对青少年和年轻成人ST使用者的相对有效性数据，并将确定申报产品是否是年轻ST使用者的可行戒烟选择，因为年轻ST使用者几乎没有有效的戒烟选择。通过对ST使用者的药物使用轨迹进行早期干预，可以在长期身体依赖和负面健康影响形成之前实现戒烟。