Multi-spectral single-scan digital lung imaging system

描述（由申请人提供）：本研究项目的长期目标是开发一种多光谱单扫描肺部成像系统。我们的主要假设是，对患者的每条路径（线积分）进行同步和共同注册的多光谱投影数据采集将有助于肺部疾病的检测和表征。该项目的核心将是开发一种快速、低噪声的全帧采样窄光圈CMOS探测器，可以扫描感兴趣的物体背后。与每个探测器行推进和全帧采样同步，x射线光谱变化（通过技术，过滤，潜在的x射线阳极跟踪和目标材料选择），以这样一种方式，通过身体的每个线积分进行成像和分析，在多个光谱上采样。因此，在解剖结构的单次扫描中，在不同的光谱条件下获得了本质上共时和共配准的多个投影图像。然后将这些图像数据分解为多个基函数（然后可以单独显示或以各种加权组合显示）。在这个应用程序的第一阶段，我们将专注于证明同时和共同注册的多光谱胸部成像的可行性。I期研究的具体目标是：(1)证实该方法用于肺癌筛查的潜力；(2)论证系统可行性。

DESCRIPTION (provided by applicant): The long-term objective of this research project is to develop a multi-spectral single-scan lung imaging system. Our primary hypothesis is that the essentially simultaneous and co-registered acquisition of multi-spectral projection data for each path (line-integral) through the patient will help in the detection and characterization of lung diseases. At the heart of the project will be the development of a fast and low-noise full-frame sampling narrow-aperture CMOS detector that can be scanned behind the body of interest. In synchronicity with each detector-row advance and full frame sampling, the x-ray spectra are varied (via techniques, filtration, and potentially x-ray anode track and target material selection) in such a way that each line-integral through the body to be imaged and analyzed is sampled at a multiplicity of spectra. As a result, in a single scan of the anatomy a multiplicity of essentially co-temporal and co-registered projection images are acquired under separate spectral conditions. These image data are then decomposed onto a multiplicity of basis functions (which may then be displayed separately or in various weighted combinations). In Phase I of this application we will focus on the proof of feasibility for co-temporal and co-registered multi-spectral chest imaging. The Specific Aims for Phase I research are to: (1) Substantiate the approach potential for lung cancer screening; (2) Demonstrate system feasibility.