New Sparker for Improved Electrohydraulic Lithotripsy

用于改进电液碎石术的新型火花器

• 批准号: 7052206
• 负责人: RAYMOND B SCHAEFER
• 金额: $ 9.87万
• 依托单位: PHOENIX SCIENCE AND TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2006-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7052206
• 关键词: biomedical equipment development; computer program /software; electrodes; kidney disorder; lithotripsy; therapy adverse effect

DESCRIPTION (provided by applicant): Shock wave lithotripsy (SWL) is the treatment of choice for kidney stones. Originally the standard lithotripter generated the shock with a sparker electrode, but their use has declined because the shocks are inconsistent, cause painful side effects and the electrode must be replaced during the procedure. New types of lithotripters are more consistent and last longer, but the clinical outcomes are not as good and side effects are greater. The goal of this research is to demonstrate the feasibility of a new type of spark electrode that produces consistent shocks, can reduce side effects and last for many procedures. The long-term goal is to develop a new commercial SWL, with reduced side effects and much longer life. The work will employ an innovative methodology and design algorithm for sparker electrodes used in Navy applications. The algorithm, developed for high energy shocks, will be scaled down for SWL. Experimental measurements using electrodes developed with this new methodology will be compared to an existing lithotripter to demonstrate improvements. A successful program will lead to a new commercial system for SWL that resolves the issues with current systems, resulting in improved clinical outcomes at lower cost. Public health may also benefit from use in additional medical applications, including healing bones, treatment of tendonitis and tumor therapy.

描述（由申请人提供）：冲击波岩石疗法（SWL）是肾结石的选择。最初，标准岩石磨牙器用Sparker电极产生冲击，但由于冲击不一致，其使用情况下降，导致疼痛的副作用，并且必须在过程中更换电极。新型的岩性磨牙器更加一致，持续更长的时间，但是临床结果并不那么好，副作用也更大。这项研究的目的是证明产生一致冲击的新型火花电极的可行性，可以减少副作用，并且在许多过程中持续持久。长期目标是开发新的商业SWL，副作用减少和更长的寿命。这项工作将采用用于海军应用中使用的Sparker电极的创新方法和设计算法。为高能冲击而开发的算法将缩放为SWL。将使用此新方法开发的电极与现有的岩石制品进行比较，以证明改进的实验测量。成功的计划将导致SWL的新商业系统，该系统可以解决当前系统的问题，从而以较低的成本改善临床结果。公共卫生也可能受益于其他医疗应用，包括愈合骨骼，治疗肌腱炎和肿瘤疗法。