Sparker Array for Improved Electrohydraulic Lithotripsy (EHL)

用于改进电液碎石术 (EHL) 的火花阵列

基本信息

项目摘要

DESCRIPTION (provided by applicant): Shock wave lithotripsy (SWL) is the first line treatment for the majority of patients with kidney stones. The gold standard in SWL is still considered to be the Dornier HM3, which was the first lithotripter introduced into the US. The HM3 is an electrohydraulic lithotripter (EHL) that uses a single underwater "sparker" as a shock wave source. The HM3 has the drawback that the electrodes erode quickly and must be replaced in the middle of a procedure, and causes significant side effects. This project is to develop optimized arrays several sparkers in small ellipsoidal reflectors that last for several procedures and break stones more effectively. The flexibility in placement of the sparkers allows space for an in-line probe to monitor stone location during treatment, which will result in fewer pressure pulses missing the stone and reduce damage to surrounding tissue. The specific project objectives are to optimize sparker arrays, including the use of double pulses by breaking both artificial and actual kidney stones, develop an in-line probe and conduct animal studies to investigate side-effects and to support an IDE. A successful Phase II will lead to the development of a prototype and clinical studies and subsequent commercialization. PUBLIC HEALTH RELEVANCE: This research can lead to improved treatment of kidney stones. A successful new lithotripter will have a higher percentage of successes (reducing the number of repeat procedures), less side effects to the patient and will operate for several procedures without having to replace the sparker (which currently is replaced during each procedure).
描述(由申请人提供):冲击波碎石术(SWL)是大多数肾结石患者的一线治疗。SWL的黄金标准仍然被认为是Dornier HM 3,这是第一台引入美国的碎石机。HM 3是一种电液碎石机(EHL),使用单个水下“火花”作为冲击波源。HM 3的缺点是电极腐蚀很快,必须在手术过程中更换,并导致严重的副作用。 本计画是开发最佳化的阵列,数个电火花在小的椭球面反射器,持续数个程序,更有效地打破石头。火花器放置的灵活性为在线探头提供了空间,以在治疗期间监测结石位置,这将导致更少的压力脉冲错过结石并减少对周围组织的损伤。 具体的项目目标是优化电火花阵列,包括使用双脉冲破碎人工和实际的肾结石,开发一种在线探针,并进行动物研究,以调查副作用和支持IDE。第二阶段的成功将导致原型和临床研究的开发以及随后的商业化。 公共卫生关系: 这项研究可以改善肾结石的治疗。成功的新碎石机将具有更高的成功率(减少重复手术的次数),对患者的副作用更少,并且将在无需更换火花器(目前在每次手术期间更换)的情况下进行几次手术。

项目成果

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RAYMOND B SCHAEFER其他文献

RAYMOND B SCHAEFER的其他文献

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{{ truncateString('RAYMOND B SCHAEFER', 18)}}的其他基金

Sparker Array for Improved Electrohydraulic Lithotripsy (EHL)
用于改进电液碎石术 (EHL) 的火花阵列
  • 批准号:
    8546338
  • 财政年份:
    2010
  • 资助金额:
    $ 47万
  • 项目类别:
Sparker Array for Improved Electro-Hydraulic Lithotripsy (EHL)
用于改进电液碎石 (EHL) 的火花阵列
  • 批准号:
    7996791
  • 财政年份:
    2010
  • 资助金额:
    $ 47万
  • 项目类别:
Development of a New Sparker Electrode for Improved Electrohydraulic Lithotripsy
开发新型火花电极以改进电液碎石术
  • 批准号:
    7873406
  • 财政年份:
    2009
  • 资助金额:
    $ 47万
  • 项目类别:
New Sparker for Improved Electrohydraulic Lithotripsy
用于改进电液碎石术的新型火花器
  • 批准号:
    7052206
  • 财政年份:
    2006
  • 资助金额:
    $ 47万
  • 项目类别:
Development of a New Sparker Electrode for Improved Electrohydraulic Lithotripsy
开发新型火花电极以改进电液碎石术
  • 批准号:
    7324279
  • 财政年份:
    2006
  • 资助金额:
    $ 47万
  • 项目类别:
Development of a New Sparker Electrode for Improved Electrohydraulic Lithotripsy
开发新型火花电极以改进电液碎石术
  • 批准号:
    7462408
  • 财政年份:
    2006
  • 资助金额:
    $ 47万
  • 项目类别:

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