Development of a New Sparker Electrode for Improved Electrohydraulic Lithotripsy

开发新型火花电极以改进电液碎石术

• 批准号: 7873406
• 负责人: RAYMOND B SCHAEFER
• 金额: $ 1.03万
• 依托单位: PHOENIX SCIENCE AND TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-16 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7873406
• 关键词: Acoustics; Address; Adverse effects; CHRM3 gene; Calculi; Clinical; Collaborations; Development; Electrodes; Electromagnetics; Exhibits; Goals; Gold; Head; Kidney Calculi; Legal patent; Length; Life; Lithotripsy; Maintenance; Maps; Marketing; Measurement; Measures; Mechanics; Names; Outcome; Output; Pain; Patients; Performance; Phase; Procedures; Reporting; Reproducibility; Research; Research Personnel; Robin bird; Schedule; Shock; Source; Spatial Distribution; System; Testing; Time; Translating; Work; base; commercialization; cost; design; feeding; improved; meetings; pressure; professor; programs; prototype

DESCRIPTION (provided by applicant): Shock wave lithotripsy (SWL) is a non-invasive treatment for kidney stones and other ailments. However, current lithotripters produce painful side effects, and the mechanisms of lithotripsy and the causes of the side effects are not fully understood. Electrohydraulic lithotripters (EHL's), which use an underwater spark as a shock wave source, had been the treatment of choice but use has declined because the shocks are inconsistent, cause painful side effects and the electrodes are short lived. Typically, the electrode head wears out during a procedure, and must be replaced before completing the procedure. New types of lithotripters are more consistent and last longer than one procedure, but their clinical outcomes are reduced and side effects are greater. Phase I showed the feasibility of using a wire-initiated sparker to produce consistent and precise shocks, of controlling the shock (for potential improved comminution of kidney stones and reduction in side effects), of lasting for many procedures. The proposed Phase II continues research towards the long-term goal to develop a new commercial EHL that exceeds the clinical outcomes of lithotripters, with reduced side effects, much longer life and lower cost. The specific project objectives are to develop a wire feed system needed to employ wire- initiated sparkers for EHL, demonstrate ultra-long lifetime using the wire-feed, map out the acoustic field of the shock and cavitation in the focal region, conduct research using the sparker's varied shock waveforms to improve comminution of kidney stones and develop a prototype wire-feed sparker for commercialization. A successful project will result in improved clinical results of SWL at reduced cost. Shock wave lithotripsy (SWL) is a non-invasive treatment for kidney stones and other ailments. The electrodes in current systems must be replaced during a procedure, and the results are inconsistent, with unpleasant side effects. A successful program will result in a new SWL system with electrodes lasting several procedures, more consistent clinical outcomes, reduced side effects and lower cost.

描述（由申请人提供）：冲击波碎石疗法（SWL）是肾结石和其他疾病的无创治疗方法。然而，当前的岩性磨牙会产生痛苦的副作用，岩石疗法的机制和副作用的原因尚不完全了解。用水下火花作为冲击波来源的电氢气碎石术（EHL）一直是选择的处理，但使用使用量下降，因为冲击不一致，导致疼痛的副作用，电极短暂。通常，电极头会在过程中磨损，并且必须在完成过程之前更换。新型的岩性磨牙器的一致性比一个程序更一致，持续时间更长，但是它们的临床结果降低，副作用更大。第一阶段显示了使用电线发射的火花产生一致和精确的冲击的可行性，该冲击是控制了电击的（有可能改善肾结石的粉刺和减少副作用的浓度），以持续许多程序。拟议的第二阶段继续研究长期目标，以开发一种超过岩石磨牙剂临床结果的新商业EHL，副作用降低，寿命更长和成本较低。特定的项目目标是开发用于使用电线发射的EHL的电线饲料系统，使用电线馈线证明了超长的寿命，绘制了焦点区域中的震动和空化的声场，使用Sparker的多样性冲击波形进行研究，以改善肾结石的冲击波形，以改善肾脏石材的冲击，并开发原型型号的火花。成功的项目将以降低的成本导致SWL的临床结果提高。冲击波碎石疗法（SWL）是肾结石和其他疾病的无创治疗方法。当前系统中的电极必须在过程中更换，并且结果不一致，副作用不愉快。成功的程序将导致新的SWL系统具有持续多个程序，更一致的临床结果，副作用降低和成本降低的电极。