Sparker Array for Improved Electrohydraulic Lithotripsy (EHL)

用于改进电液碎石术 (EHL) 的火花阵列

基本信息

项目摘要

DESCRIPTION (provided by applicant): Shock wave lithotripsy (SWL) is the first line treatment for the majority of patients with kidney stones. The gold standard in SWL is still considered to be the Dornier HM3, which was the first lithotripter introduced into the US. The HM3 is an electrohydraulic lithotripter (EHL) that uses a single underwater "sparker" as a shock wave source. The HM3 has the drawback that the electrodes erode quickly and must be replaced in the middle of a procedure, and causes significant side effects. This project is to develop optimized arrays several sparkers in small ellipsoidal reflectors that last for several procedures and break stones more effectively. The flexibility in placement of the sparkers allows space for an in-line probe to monitor stone location during treatment, which will result in fewer pressure pulses missing the stone and reduce damage to surrounding tissue. The specific project objectives are to optimize sparker arrays, including the use of double pulses by breaking both artificial and actual kidney stones, develop an in-line probe and conduct animal studies to investigate side-effects and to support an IDE. A successful Phase II will lead to the development of a prototype and clinical studies and subsequent commercialization.
描述(由申请人提供):冲击波碎石术(SWL)是大多数肾结石患者的一线治疗方法。 SWL 的黄金标准仍然被认为是 Dornier HM3,它是美国引进的第一台碎石机。 HM3 是一种电动液压碎石机 (EHL),使用单个水下“火花器”作为冲击波源。 HM3 的缺点是电极很快就会腐蚀,必须在手术过程中更换,并会造成严重的副作用。 该项目旨在开发小型椭圆形反射器中的多个火花器的优化阵列,这些火花器可以持续多个程序并更有效地破碎石头。火花塞放置的灵活性为在线探针提供了空间,以在治疗期间监测结石位置,这将导致错过结石的压力脉冲减少,并减少对周围组织的损伤。 具体项目目标是优化火花阵列,包括通过打破人造肾结石和实际肾结石使用双脉冲、开发在线探针并进行动物研究以调查副作用并支持 IDE。第二阶段的成功将导致原型开发和临床研究以及随后的商业化。

项目成果

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RAYMOND B SCHAEFER其他文献

RAYMOND B SCHAEFER的其他文献

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{{ truncateString('RAYMOND B SCHAEFER', 18)}}的其他基金

Sparker Array for Improved Electro-Hydraulic Lithotripsy (EHL)
用于改进电液碎石 (EHL) 的火花阵列
  • 批准号:
    7996791
  • 财政年份:
    2010
  • 资助金额:
    $ 51.9万
  • 项目类别:
Sparker Array for Improved Electrohydraulic Lithotripsy (EHL)
用于改进电液碎石术 (EHL) 的火花阵列
  • 批准号:
    8310488
  • 财政年份:
    2010
  • 资助金额:
    $ 51.9万
  • 项目类别:
Development of a New Sparker Electrode for Improved Electrohydraulic Lithotripsy
开发新型火花电极以改进电液碎石术
  • 批准号:
    7873406
  • 财政年份:
    2009
  • 资助金额:
    $ 51.9万
  • 项目类别:
New Sparker for Improved Electrohydraulic Lithotripsy
用于改进电液碎石术的新型火花器
  • 批准号:
    7052206
  • 财政年份:
    2006
  • 资助金额:
    $ 51.9万
  • 项目类别:
Development of a New Sparker Electrode for Improved Electrohydraulic Lithotripsy
开发新型火花电极以改进电液碎石术
  • 批准号:
    7324279
  • 财政年份:
    2006
  • 资助金额:
    $ 51.9万
  • 项目类别:
Development of a New Sparker Electrode for Improved Electrohydraulic Lithotripsy
开发新型火花电极以改进电液碎石术
  • 批准号:
    7462408
  • 财政年份:
    2006
  • 资助金额:
    $ 51.9万
  • 项目类别:

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