Sparker Array for Improved Electro-Hydraulic Lithotripsy (EHL)

用于改进电液碎石 (EHL) 的火花阵列

• 批准号: 7996791
• 负责人: RAYMOND B SCHAEFER
• 金额: $ 9.82万
• 依托单位: PHOENIX SCIENCE AND TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7996791
• 关键词: Adverse effects; CHRM3 gene; Calculi; Clinical; Collaborations; Coupling; Electrodes; Goals; Gold; Kidney Calculi; Lead; Life; Liquid substance; Lithotripsy; Location; Monitor; Names; Outcome; Patients; Performance; Phase; Procedures; Pulse Pressure; Research; Research Personnel; Robin bird; Shock; Source; Surface; Technology; Time; Tissues; Ultrasonography; clinical application; flexibility; improved; innovation; meetings; pressure; professor; prototype; public health relevance; success

DESCRIPTION (provided by applicant): Shock wave lithotripsy (SWL) is the first line treatment for the majority of patients with kidney stones. The gold standard in SWL is still considered to be the Dornier HM3, which was the first lithotripter introduced into the US. The HM3 is an electrohydraulic lithotripter (EHL) that uses a single underwater "sparker" as a shock wave source. The HM3 has the drawback that the electrodes erode quickly and must be replaced in the middle of a procedure, and causes significant side effects. This project is to demonstrate that an array of several sparkers in small ellipsoidal reflectors can break stones without having to stop a procedure. The relatively low electrical current in each sparker in the array reduces the erosion, which may allow the sparker array to operate for multiple treatments. The flexibility in placement of the sparkers allows space for an in-line ultrasound probe to monitor stone location during treatment, which will result in fewer pressure pulses missing the stone and reduce damage to surrounding tissue. The specific project objectives are to develop a sparker array and demonstrate its efficacy by breaking artificial stones without having to replace electrodes. A successful Phase I will lead to a Phase II to develop a prototype and demonstrate the potential for improved clinical outcomes. PUBLIC HEALTH RELEVANCE: This research can lead to improved treatment of kidney stones. A successful new lithotripter will have both a higher percentage of successes (reducing the number of repeat procedures) and less side effects to the patient.

描述（由申请人提供）：冲击波碎石疗法（SWL）是大多数肾结石患者的第一行治疗。 SWL中的黄金标准仍被认为是Dornier HM3，它是第一个引入美国的岩石片。 HM3是使用单个水下“ Sparker”作为冲击波源的电氢气岩石磨牙（EHL）。 HM3的缺点是电极快速侵蚀，必须在过程的中间替换，并引起显着的副作用。 该项目是为了证明小椭圆形反射器中的几个火花阵列可以破坏石头而无需停止程序。阵列中每个火花中的相对较低的电流减少了侵蚀，这可能使Sparker阵列可以进行多种处理。放置火花的灵活性使在线超声探头可以在治疗过程中监测石头位置的空间，这将导致较少的压力脉冲缺少石头并减少周围组织的损害。 特定的项目目标是开发一个火花阵列，并通过破坏人造石头而无需更换电极来证明其功效。成功的一阶段将导致II期发展原型，并证明改善临床结果的潜力。 公共卫生相关性：这项研究可以改善对肾结石的治疗。成功的新岩石制剂将获得更高的成功百分比（减少重复程序的数量），又对患者的副作用较小。