Project to be confirmed after rotation year

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Epidemiological studies provide strong evidence that obese mothers give birth tobabies who are themselves predisposed to obesity and poor metabolic health asadults, and this phenomenon can be replicated in mouse models. This suggests thatthe tissues in the adult offspring of obese mothers 'remember' the adverse conditionsduring early life. However, the molecular mechanisms that link early life events toadult metabolic state are poorly understood. We will test the hypothesis that duringdevelopment offspring tissues and stem cells acquire metabolite-derived epigeneticmarks that are propagated to adult organs and modify obesity risk.