Project to be confirmed after rotation year

项目待轮换年后确认

• 批准号: 2854469
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2854469
• 关键词: Project; confirmed; after; rotation; year

Epidemiological studies provide strong evidence that obese mothers give birth tobabies who are themselves predisposed to obesity and poor metabolic health asadults, and this phenomenon can be replicated in mouse models. This suggests thatthe tissues in the adult offspring of obese mothers 'remember' the adverse conditionsduring early life. However, the molecular mechanisms that link early life events toadult metabolic state are poorly understood. We will test the hypothesis that duringdevelopment offspring tissues and stem cells acquire metabolite-derived epigeneticmarks that are propagated to adult organs and modify obesity risk.

流行病学研究提供了强有力的证据，表明肥胖母亲生下的婴儿本身就容易肥胖且成年后代谢健康状况不佳，并且这种现象可以在小鼠模型中复制。这表明肥胖母亲的成年后代的组织“记住”了早年的不利条件。然而，人们对将早期生命事件与成人代谢状态联系起来的分子机制知之甚少。我们将检验这样的假设：在发育过程中，后代组织和干细胞获得代谢物衍生的表观遗传标记，这些标记会传播到成年器官并改变肥胖风险。