Project to be confirmed after rotation year

项目待轮换年后确认

• 批准号: 2855195
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2855195
• 关键词: Project; confirmed; after; rotation; year

Prior exposure to one virus can confer a degree of protection to another, a processtermed cross-protective immunity. With over 200 species of virus known to infecthumans, the degree of cross-immunity may be an important contributor to whichviruses successfully spread in humans, livestock and companion animals. Harnessingcross-reactive T-cell immunity across variable viral systems holds promise fordesigning vaccines for current and future zoonotic threats. Here, using a pairedbioinformatic and immunology approach, we will deconvolute the fundamental rulesdetermining T-cell cross-reactivity by precisely characterising the interplay betweenviral evolution and T-cell specificity across host and viral species.

先前接触一种病毒可以给另一种病毒提供一定程度的保护，即经过加工的交叉保护免疫。已知可感染人类的病毒超过200种，交叉免疫的程度可能是病毒在人类、牲畜和伴侣动物中成功传播的一个重要因素。利用跨不同病毒系统的交叉反应性t细胞免疫为设计针对当前和未来人畜共患病威胁的疫苗提供了希望。在这里，我们将使用生物信息学和免疫学的方法，通过精确地描述宿主和病毒物种之间的环境进化和t细胞特异性之间的相互作用，来解开决定t细胞交叉反应性的基本规则。