Project to be confirmed after rotation year

事先接触一种病毒可以为另一种病毒提供一定程度的保护，即交叉保护免疫。由于已知感染拇指的病毒有200多种，交叉免疫程度可能是病毒在人类、牲畜和同伴动物中成功传播的一个重要因素。利用跨不同病毒系统的交叉反应性T细胞免疫有望为当前和未来的人畜共患威胁设计疫苗。在这里，使用生物信息学和免疫学相结合的方法，我们将通过精确表征宿主和病毒物种之间的病毒进化和T细胞特异性之间的相互作用，来揭示决定T细胞交叉反应的基本规则。

Prior exposure to one virus can confer a degree of protection to another, a processtermed cross-protective immunity. With over 200 species of virus known to infecthumans, the degree of cross-immunity may be an important contributor to whichviruses successfully spread in humans, livestock and companion animals. Harnessingcross-reactive T-cell immunity across variable viral systems holds promise fordesigning vaccines for current and future zoonotic threats. Here, using a pairedbioinformatic and immunology approach, we will deconvolute the fundamental rulesdetermining T-cell cross-reactivity by precisely characterising the interplay betweenviral evolution and T-cell specificity across host and viral species.