Project to be confirmed after rotation year

随着年龄的增长，人们患残疾和虚弱的风险增加。衰老的生物学机制越来越被理解，包括基因表达、干细胞和免疫力的控制下降。这些衰老标记可以用药物靶向治疗，在实验室动物和人类中，以改善衰老过程中的健康状况。该项目将利用多个数据库中的丰富信息，包括英国生物银行和研究文献，以确定导致与年龄有关的问题的关键年龄标志，并有针对性地打击他们。根据学生的兴趣，实验跟进是可能的。

As people get older they become at increased risk of disability and frailty. Thebiological mechanisms of ageing are increasingly well understood and include, forinstance, declining control of gene expression, stem cells and immunity. These ageinghallmarks can be targeted with drugs, in both laboratory animals and humans, toimprove health during ageing. This project will exploit the rich information in multipledatabases, including UK Biobank and the research literature, to identify the key ageinghallmarks that lead to age-related problems, and that could be targeted to combatthem. Depending on student interests, experimental follow up would be possible.