Nanocoatings for Biomedical Implants

用于生物医学植入物的纳米涂层

• 批准号: 7115313
• 负责人: Huinan Hannah Liu
• 金额: $ 21.15万
• 依托单位: NANOMECH, LLC
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7115313
• 关键词: biomaterial development /preparation; biomaterial interface interaction; dental implants; dental materials; hydroxyapatites; nanotechnology; surface coating; titanium

DESCRIPTION (provided by applicant): It is proposed to develop a nanoparticle coating of hydroxyapatite (HAp) on titanium dental implants. Osseointegration is of critical importance in dental implant surgical operation because it is affected by the proper selection of construction materials, design, and surgical techniques. Fast fixation and durability of dental implants have long been sought by dental implant manufacturers and implant surgical specialists. The proposed nanoparticle coating is expected to provide good adhesion, controlled phases for durability, and controlled pore size for promoting tissue growth. The coating will be fabricated using a hybrid process of electrostatic spray coating and microwave sintering or laser sintering. The average pore size, surface roughness, phase, and the adhesion of the coating will be measured. The mechanical properties, including the strength and the fracture toughness of the coated dental implants, will be tested. The proposed nanoparticle coating technique offers high deposition rate, suitability for various composite coatings, compatibility to simple and complex geometry, flexibility, and low cost. We anticipate that the application of this coating technique will eliminate the formation of amorphous HAp, which is easily dissolved into body fluid and affects the interfacial adhesion.

描述（由申请人提供）：拟在钛牙科种植体上开发羟基磷灰石（HAp）纳米颗粒涂层。种植体骨整合在种植外科手术中至关重要，因为它受到构建材料、设计和手术技术的影响。牙种植体的快速固定和耐久性长期以来一直是牙种植体制造商和种植外科专家所追求的。预计拟议的纳米颗粒涂层将提供良好的粘附性、耐久性的受控相以及促进组织生长的受控孔径。涂层将使用静电喷涂和微波烧结或激光烧结的混合工艺制造。将测量涂层的平均孔径、表面粗糙度、相和附着力。将测试机械性能，包括涂层牙种植体的强度和断裂韧性。所提出的纳米颗粒涂层技术提供了高沉积速率，适用于各种复合涂层，兼容简单和复杂的几何形状，灵活性和低成本。我们预计，这种涂层技术的应用将消除无定形HAp的形成，这是很容易溶解到体液中，影响界面粘附。