Nanocoatings for Biomedical Implants

用于生物医学植入物的纳米涂层

• 批准号: 7115313
• 负责人: Huinan Hannah Liu
• 金额: $ 21.15万
• 依托单位: NANOMECH, LLC
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7115313
• 关键词: biomaterial development /preparation; biomaterial interface interaction; dental implants; dental materials; hydroxyapatites; nanotechnology; surface coating; titanium

DESCRIPTION (provided by applicant): It is proposed to develop a nanoparticle coating of hydroxyapatite (HAp) on titanium dental implants. Osseointegration is of critical importance in dental implant surgical operation because it is affected by the proper selection of construction materials, design, and surgical techniques. Fast fixation and durability of dental implants have long been sought by dental implant manufacturers and implant surgical specialists. The proposed nanoparticle coating is expected to provide good adhesion, controlled phases for durability, and controlled pore size for promoting tissue growth. The coating will be fabricated using a hybrid process of electrostatic spray coating and microwave sintering or laser sintering. The average pore size, surface roughness, phase, and the adhesion of the coating will be measured. The mechanical properties, including the strength and the fracture toughness of the coated dental implants, will be tested. The proposed nanoparticle coating technique offers high deposition rate, suitability for various composite coatings, compatibility to simple and complex geometry, flexibility, and low cost. We anticipate that the application of this coating technique will eliminate the formation of amorphous HAp, which is easily dissolved into body fluid and affects the interfacial adhesion.

描述（由申请人提供）：建议在钛牙齿植入物上开发羟基磷灰石（HAP）的纳米颗粒涂层。骨整合在牙科植入物手术操作中至关重要，因为它受到适当选择建筑材料，设计和手术技术的影响。长期以来，牙科植入物制造商和植入物手术专家一直在寻求牙科植入物的快速固定和耐用性。提出的纳米颗粒涂层有望提供良好的粘附，可控制的相位耐用性以及受控的孔径，以促进组织生长。涂层将使用静电喷涂涂层和微波烧结或激光烧结的混合过程制成。将测量平均孔径，表面粗糙度，相位和涂层的粘附。将测试机械性能，包括涂层牙科植入物的强度和断裂韧性。所提出的纳米颗粒涂料技术可提供高沉积速率，适合各种复合涂料，兼容简单和复杂的几何形状，柔韧性和低成本。我们预计，这种涂料技术的应用将消除无定形HAP的形成，这很容易溶解在体液中并影响界面粘附。