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Antibacterial Biocompatible Bioresorbable Alloys for Musculoskeletal Implants

用于肌肉骨骼植入物的抗菌生物相容性生物可吸收合金

基本信息

批准号：
9038737
负责人：
Huinan Hannah Liu
金额：
$ 6.9万
依托单位：
UNIVERSITY OF CALIFORNIA RIVERSIDE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-04-01 至 2019-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9038737
关键词：
3D Print Address Alloys Aluminum Animal Model Anti-Bacterial Agents Antibiotic Resistance Antibiotics Bacteria Bacterial Adhesion Biocompatible Biological Biomechanics Bone Growth Bone Marrow Bone Regeneration Calcium Caring Cell Adhesion Cell physiology Clinical Defect Deposition Devices Elements Engineering Equation Evaluation Excision Femur Fracture Fracture Fixation Goals Grant Guidelines Healed Health Health Care Costs Healthcare Histology Immune system Implant In Vitro Industry Infection Infection prevention Knowledge Lead Ligaments Location Magnesium Mechanics Mesenchymal Stem Cells Metals Microbial Biofilms Minerals Mission Modeling Morbidity - disease rate Musculoskeletal Natural regeneration Nutrient Operative Surgical Procedures Osteogenesis Osteomyelitis Patients Pilot Projects Play Property Rare Earth Metals Rattus Research Research Personnel Scanning Electron Microscopy Sterility Techniques Technology Transfer Toxic effect Translations United States National Institutes of Health Weight-Bearing state Work Zinc bactericide base biomaterial compatibility bone bone cell bone healing bone loss care burden commercialization cost design follow-up healing implantable device implantation improved in vivo innovation interest materials science medical implant methicillin resistant Staphylococcus aureus novel osteogenic pathogenic bacteria preclinical study public health relevance reconstruction repaired response sample fixation scaffold tibia tomography

项目摘要

DESCRIPTION (provided by applicant): The goal of this project is to investigate antibacterial property and biocompatibility of a new class of bioresorbable alloys for musculoskeletal repair and reconstruction. Despite advanced sterile surgical techniques and antibiotics, periprosthetic infections (PPI) still occur, and they are clinically challenging to treat. Once infected, these implants often require surgical removal because systemic administration of antibiotics does not provide adequate local antibiotic concentration and is ineffective when a biofilm forms, which leads to prolonged morbidity and significant health care burden. Thus, antibacterial biocompatible bioresorbable alloys are needed to mitigate these problems to reduce secondary surgeries, patient discomfort, and health care costs. Magnesium (Mg) alloys represent a promising new class of bioresorbable metals, providing complementary properties that are absent in implants available today. Commercially available pure Mg degrades too fast and is mechanically too weak for the surgical needs, while commercial Mg alloys contain aluminum (Al) or rare earth (RE) elements that pose serious concerns of long-term toxicity. The PI has engineered a novel class of Mg alloy composed of biocompatible elements that provide slower degradation and greater mechanical strength. The objective of this project is to determine antibacterial property and biocompatibility of the new Mg alloys for potential implant applications, e.g., fixation plates, screws, pins, and K-wires. The central hypothesis is that alloying Mg rationally with zinc (Zn) and calcium (Ca) will induce desirable biological responses in vitro and in vivo. The desirable biological responses for musculoskeletal implant applications include enhanced bone cell functions and regeneration, and reduced bacterial adhesion and viability on the new alloys, thus preventing infection. The central hypothesis is established based on the PI's prior results and positive effects of Mg, Zn, and Ca as essential nutrients for bone repair and immune system health. This project is innovative because the alloy design integrates biological benefits into the materials science tetrahedron to achieve synergistic properties for preventing infection and improving healing. Further, the approach for creating infection-free implants is innovative because it does not rely on antibiotics, and reduce the emergence of antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), a common osteomyelitis-inducing pathogenic bacterium. This project is significant because it will produce critical knowledge on antibacterial property of Mg-Zn-Ca alloys and their biocompatibility for musculoskeletal implant applications, and overcome the critical gap toward preclinical studies and clinical translation.