Nutrient-Derived Alloys with Nanostructured Surfaces for Distraction Osteogenesis
用于牵引成骨的具有纳米结构表面的营养衍生合金
基本信息
- 批准号:10306931
- 负责人:
- 金额:$ 8.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-12-01 至 2022-11-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAlloysAnti-Bacterial AgentsAntibioticsBacteriaBacterial AdhesionBacterial Antibiotic ResistanceBiologicalBone DiseasesBone GrowthBone Marrow CellsBone RegenerationCalciumCellsChildClinicalCoupledCouplingDefectDeformityDevice RemovalDevicesDisadvantagedDistraction OsteogenesisEngineeringEquipment MalfunctionGeneral AnesthesiaImmuneIn VitroIndustryInfectionKnowledgeMagnesiumMechanicsMedical DeviceModelingNanostructuresNutrientOperative Surgical ProceduresOutcomePatientsPropertyResearchSkeletonSurfaceSurgical complicationTechniquesTechnology TransferUnited StatesZincantimicrobialbiomaterial compatibilitybonebone cellclinical translationcraniomaxillofacialcrystallinitydesigndevelopmental diseasedistractionimmune healthimplantable deviceimprovedin vivoinnovationinterestmaterials sciencemechanical propertiesmeetingsnoveloperationpathogenic bacteriapediatric patientspreclinical studypublic health relevancerepairedresponsesocial
项目摘要
Project Summary
Defects in craniomaxillofacial (CMF) skeleton affect thousands of babies every year in the United States. For
repairing moderate to severe bone deficiency, a surgical technique called distraction osteogenesis (DO) is fre-
quently used to gradually lengthen abnormal bones in pediatric patients. In contrast to external devices, internal
distraction devices (IDD) implanted directly to the bone are safer to wear for a period of several months, more
comfortable to the patients without social discomfort, and, therefore, permit greater retention periods, which
provide better long-term stability than external devices. However, their major disadvantage is that they require a
second invasive operation under general anesthesia for device removal. Moreover, infections of distraction de-
vices cause poor bone growth and complications that require additional revision surgeries. This project will pro-
vide a promising solution of bioresorbable antimicrobial devices that eliminate the secondary surgeries and in-
fection-induced complications, thus improving clinical outcome. The PI has engineered a new class of Mg alloy
via coupling biocompatible nutrient elements Mg, zinc (Zn) and calcium (Ca) with novel alloy processing and
surface treatment, which not only provide the needed mechanical and degradation properties, but also induce
desirable cellular responses for bone growth and antimicrobial property. The PI has demonstrated antibacterial
property and bioactivity of the new Mg alloys with nanostructured surfaces in vitro using pathogenic bacteria and
relevant bone marrow cells. The objective of this project is to fabricate a model internal distraction device (IDD)
using the crystalline Mg-Zn-Ca alloys coupled with nanostructured surfaces and verify the antibacterial property,
bioactivity, biocompatibility, and mechanical properties in vivo. The central hypothesis is that the IDDs made of
the bioresorbable alloys with nanostructured surfaces will reduce bacterial adhesion and viability in vivo while
meeting the requirements of mechanical properties and bioactivity for distraction osteogenesis (DO), built on the
PI’s prior results and positive effects of Mg, Zn, and Ca as essential nutrients for bone repair and immune system
health. This project is innovative because the alloy design, processing, and nanostructured surface treatment
synergize biological benefits with materials science tetrahedron to achieve integrated mechanical and biological
properties. Further, the approach for creating infection-free IDDs is innovative because it does not rely on anti-
biotics, and reduce the emergence of antibiotic-resistant bacteria. This project is significant because it will over-
come the critical knowledge gap on the in vivo interactions of bioresorbable IDDs with bacteria, crucial bone cells
and immune cells, and thus advance the new devices toward preclinical studies and clinical translation. This
research will lead to new solutions for repairing CMF bone deformities in children and eliminating device-asso-
ciated complications.
项目摘要
在美国,每年有数以千计的婴儿受到颅颌面部骨骼缺陷的影响。为
修复中到重度的骨缺失,一种被称为牵张成骨(DO)的外科技术被用来修复中到重度的骨缺失。
用于逐渐延长儿科患者的异常骨骼。与外部设备相比,内部
直接植入骨骼的牵引器(IDD)佩戴几个月更安全
患者感到舒适,没有社交不适,因此允许更长的保留期,这
提供比外部设备更好的长期稳定性。然而,它们的主要缺点是需要一个
全麻下二次侵入性手术取器。此外,分散注意力的感染-
恶习会导致骨骼生长不良和并发症,需要额外的翻修手术。该项目将促进-
通过一种有希望的生物可吸收抗菌装置的解决方案,消除了二次手术和在
感染引起的并发症,从而改善临床结局。PI制造出了一种新型的镁合金
通过将生物相容的营养元素镁、锌(锌)和钙(钙)与新的合金加工和
表面处理,不仅提供所需的机械和降解性能,而且还
对骨骼生长和抗菌性能有良好的细胞反应。PI已经显示出抗菌作用
新型纳米表面镁合金的体外致病菌和生物活性研究
相关骨髓细胞。本课题的目的是研制一种新型的内牵张器。
将晶态的镁锌钙合金与纳米结构表面偶联并验证其抗菌性能,
体内生物活性、生物相容性和机械性能。中心假设是IDDS由
具有纳米结构表面的生物可吸收合金会降低细菌在体内的粘附性和生存能力,而
满足牵张成骨(DO)的力学性能和生物活性要求
镁、锌、钙作为骨修复和免疫系统必需营养素的前期研究结果和积极作用
健康。该项目具有创新性,因为合金设计、加工和纳米结构表面处理
与材料科学四面体协同生物效益,实现机械与生物一体化
属性。此外,创建无感染IDDS的方法是创新的,因为它不依赖于
生物制剂,并减少抗生素耐药性细菌的出现。这个项目意义重大,因为它将结束-
填补可生物吸收IDDS与细菌、关键骨细胞体内相互作用的关键知识空白
和免疫细胞,从而推动新设备走向临床前研究和临床翻译。这
研究将为修复儿童CMF骨畸形和消除设备-ASSO-带来新的解决方案
相关并发症。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro.
纳米粒子和纳米结构表面的体外抗菌活性评价。
- DOI:10.3791/64712
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Holt-Torres,PatriciaS;Chen,Yiqing;Liu,HuinanHannah
- 通讯作者:Liu,HuinanHannah
Antimicrobial Properties of MgO Nanostructures on Magnesium Substrates.
- DOI:10.1021/acsomega.0c03151
- 发表时间:2020-09-29
- 期刊:
- 影响因子:4.1
- 作者:Lin J;Nguyen NT;Zhang C;Ha A;Liu HH
- 通讯作者:Liu HH
Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro.
研究体外可生物降解植入材料的直接和间接培养方法。
- DOI:10.3791/63065
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Xu,Changlu;Chen,Yiqing;Lin,Jiajia;Liu,HuinanH
- 通讯作者:Liu,HuinanH
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Huinan Hannah Liu其他文献
Huinan Hannah Liu的其他文献
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{{ truncateString('Huinan Hannah Liu', 18)}}的其他基金
Nutrient-Derived Alloys with Nanostructured Surfaces for Distraction Osteogenesis
用于牵引成骨的具有纳米结构表面的营养衍生合金
- 批准号:
9895281 - 财政年份:2019
- 资助金额:
$ 8.43万 - 项目类别:
Nutrient-Derived Alloys with Nanostructured Surfaces for Distraction Osteogenesis
用于牵引成骨的具有纳米结构表面的营养衍生合金
- 批准号:
10063989 - 财政年份:2019
- 资助金额:
$ 8.43万 - 项目类别:
Antibacterial Biocompatible Bioresorbable Alloys for Musculoskeletal Implants
用于肌肉骨骼植入物的抗菌生物相容性生物可吸收合金
- 批准号:
9038737 - 财政年份:2016
- 资助金额:
$ 8.43万 - 项目类别:
Antibacterial Biocompatible Bioresorbable Alloys for Musculoskeletal Implants
用于肌肉骨骼植入物的抗菌生物相容性生物可吸收合金
- 批准号:
9251239 - 财政年份:2016
- 资助金额:
$ 8.43万 - 项目类别:
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