权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Nutrient-Derived Alloys with Nanostructured Surfaces for Distraction Osteogenesis

用于牵引成骨的具有纳米结构表面的营养衍生合金

基本信息

批准号：
10306931
负责人：
Huinan Hannah Liu
金额：
$ 8.43万
依托单位：
UNIVERSITY OF CALIFORNIA RIVERSIDE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-12-01 至 2022-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10306931
关键词：
Address Affect Alloys Anti-Bacterial Agents Antibiotics Bacteria Bacterial Adhesion Bacterial Antibiotic Resistance Biological Bone Diseases Bone Growth Bone Marrow Cells Bone Regeneration Calcium Cells Child Clinical Coupled Coupling Defect Deformity Device Removal Devices Disadvantaged Distraction Osteogenesis Engineering Equipment Malfunction General Anesthesia Immune In Vitro Industry Infection Knowledge Magnesium Mechanics Medical Device Modeling Nanostructures Nutrient Operative Surgical Procedures Outcome Patients Property Research Skeleton Surface Surgical complication Techniques Technology Transfer United States Zinc antimicrobial biomaterial compatibility bone bone cell clinical translation craniomaxillofacial crystallinity design developmental disease distraction immune health implantable device improved in vivo innovation interest materials science mechanical properties meetings novel operation pathogenic bacteria pediatric patients preclinical study public health relevance repaired response social

项目摘要

Project Summary Defects in craniomaxillofacial (CMF) skeleton affect thousands of babies every year in the United States. For repairing moderate to severe bone deficiency, a surgical technique called distraction osteogenesis (DO) is fre- quently used to gradually lengthen abnormal bones in pediatric patients. In contrast to external devices, internal distraction devices (IDD) implanted directly to the bone are safer to wear for a period of several months, more comfortable to the patients without social discomfort, and, therefore, permit greater retention periods, which provide better long-term stability than external devices. However, their major disadvantage is that they require a second invasive operation under general anesthesia for device removal. Moreover, infections of distraction de- vices cause poor bone growth and complications that require additional revision surgeries. This project will pro- vide a promising solution of bioresorbable antimicrobial devices that eliminate the secondary surgeries and in- fection-induced complications, thus improving clinical outcome. The PI has engineered a new class of Mg alloy via coupling biocompatible nutrient elements Mg, zinc (Zn) and calcium (Ca) with novel alloy processing and surface treatment, which not only provide the needed mechanical and degradation properties, but also induce desirable cellular responses for bone growth and antimicrobial property. The PI has demonstrated antibacterial property and bioactivity of the new Mg alloys with nanostructured surfaces in vitro using pathogenic bacteria and relevant bone marrow cells. The objective of this project is to fabricate a model internal distraction device (IDD) using the crystalline Mg-Zn-Ca alloys coupled with nanostructured surfaces and verify the antibacterial property, bioactivity, biocompatibility, and mechanical properties in vivo. The central hypothesis is that the IDDs made of the bioresorbable alloys with nanostructured surfaces will reduce bacterial adhesion and viability in vivo while meeting the requirements of mechanical properties and bioactivity for distraction osteogenesis (DO), built on the PI’s prior results and positive effects of Mg, Zn, and Ca as essential nutrients for bone repair and immune system health. This project is innovative because the alloy design, processing, and nanostructured surface treatment synergize biological benefits with materials science tetrahedron to achieve integrated mechanical and biological properties. Further, the approach for creating infection-free IDDs is innovative because it does not rely on anti- biotics, and reduce the emergence of antibiotic-resistant bacteria. This project is significant because it will over- come the critical knowledge gap on the in vivo interactions of bioresorbable IDDs with bacteria, crucial bone cells and immune cells, and thus advance the new devices toward preclinical studies and clinical translation. This research will lead to new solutions for repairing CMF bone deformities in children and eliminating device-asso- ciated complications.

项目摘要在美国，每年有数以千计的婴儿受到颅颌面部骨骼缺陷的影响。为修复中到重度的骨缺失，一种被称为牵张成骨(DO)的外科技术被用来修复中到重度的骨缺失。用于逐渐延长儿科患者的异常骨骼。与外部设备相比，内部直接植入骨骼的牵引器(IDD)佩戴几个月更安全患者感到舒适，没有社交不适，因此允许更长的保留期，这提供比外部设备更好的长期稳定性。然而，它们的主要缺点是需要一个全麻下二次侵入性手术取器。此外，分散注意力的感染- 恶习会导致骨骼生长不良和并发症，需要额外的翻修手术。该项目将促进- 通过一种有希望的生物可吸收抗菌装置的解决方案，消除了二次手术和在感染引起的并发症，从而改善临床结局。PI制造出了一种新型的镁合金通过将生物相容的营养元素镁、锌(锌)和钙(钙)与新的合金加工和表面处理，不仅提供所需的机械和降解性能，而且还对骨骼生长和抗菌性能有良好的细胞反应。PI已经显示出抗菌作用新型纳米表面镁合金的体外致病菌和生物活性研究相关骨髓细胞。本课题的目的是研制一种新型的内牵张器。将晶态的镁锌钙合金与纳米结构表面偶联并验证其抗菌性能，体内生物活性、生物相容性和机械性能。中心假设是IDDS由具有纳米结构表面的生物可吸收合金会降低细菌在体内的粘附性和生存能力，而满足牵张成骨(DO)的力学性能和生物活性要求镁、锌、钙作为骨修复和免疫系统必需营养素的前期研究结果和积极作用健康。该项目具有创新性，因为合金设计、加工和纳米结构表面处理与材料科学四面体协同生物效益，实现机械与生物一体化属性。此外，创建无感染IDDS的方法是创新的，因为它不依赖于生物制剂，并减少抗生素耐药性细菌的出现。这个项目意义重大，因为它将结束- 填补可生物吸收IDDS与细菌、关键骨细胞体内相互作用的关键知识空白和免疫细胞，从而推动新设备走向临床前研究和临床翻译。这研究将为修复儿童CMF骨畸形和消除设备-ASSO-带来新的解决方案相关并发症。