INDUCTION OF PLASMODIUM INFECTIONS TO SUPPORT MALARIA VACCINE STUDIES

诱导疟原虫感染以支持疟疾疫苗研究

• 批准号: 7349142
• 负责人: WILLIAM E COLLINS
• 金额: $ 4.01万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-09 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349142
• 关键词: Pan; Plasmodium; antigens; antiserum; blood; genetics; immunologic substance development /preparation; infection; malaria vaccines; monoclonal antibody

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Short-term infections were induced in chimpanzees to obtain blood-stage parasites for genetic engineering studies, the extraction of antigen for serologic tests and the infection of mosquitoes through membrane feeding to produce infected mosquitoes for genetic engineering studies, production of monoclonal antibodies, sporozoite antigens for serologic testing, to test the efficacy of transmission-blocking and anti-sporozoite vaccines, and the production of immune sera. During the year 3 chimpanzees were infected with Plasmodium ovale; from these animals blood was collected and then used for these studies or frozen for future studies.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。对黑猩猩进行短期感染，以获得用于基因工程研究的血期寄生虫，提取用于血清学测试的抗原，并通过膜喂养感染蚊子以产生用于基因工程研究的受感染蚊子，生产用于血清学测试的单抗和子孢子抗原，以测试传播阻断和抗子孢子疫苗的效果，并生产免疫血清。在这一年里，3只黑猩猩感染了卵形疟原虫；从这些动物身上采集血液，然后用于这些研究或冷冻以供将来研究。