INDUCTION OF PLASMODIUM INFECTIONS TO SUPPORT MALARIA VACCINE STUDIES

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 在黑猩猩中诱导短期感染以获得用于基因工程研究的血液期寄生虫，提取用于血清学试验的抗原，并通过膜喂养感染蚊子以产生用于基因工程研究的感染蚊子，生产单克隆抗体，子孢子抗原用于血清学试验，以测试传播阻断和抗子孢子疫苗的效力，以及生产免疫血清。在这一年中，三只黑猩猩感染了卵形疟原虫;从这些动物身上收集血液，然后用于这些研究或冷冻用于未来的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Short-term infections were induced in chimpanzees to obtain blood-stage parasites for genetic engineering studies, the extraction of antigen for serologic tests and the infection of mosquitoes through membrane feeding to produce infected mosquitoes for genetic engineering studies, production of monoclonal antibodies, sporozoite antigens for serologic testing, to test the efficacy of transmission-blocking and anti-sporozoite vaccines, and the production of immune sera. During the year three chimpanzees were infected with Plasmodium ovale; from these animals blood was collected and then used for these studies or frozen for future studies.