ENDOMETRIAL CYCLES IN VERVET MONKEYS (CERCOPITHECUS AETHIOPS)

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Old world nonhuman primates, especially macaques, have long been the experimental animal model of choice for studies of hormone action in the endometrium. Macaques are becoming increasingly difficult to obtain and it is important to assess other primate animal models for studies on the reproductive tract. The African green monkey or Vervet is a menstruating nonhuman primate with menstrual cycles of similar duration to those of women. The potential use of Vervets for studies in reproduction has been explored previously. Those studies revealed that menstruation is very light in this species and that daily testing by vaginal swab is required in order to detect menses. The physiological mechanism underlying the attenuated menstruation in this species has not been previously explored. Therefore, our goal was to assess the cyclic effects of estradiol (E2) and progesterone (P) on the regulation of menstruation this species.