ENDOMETRIAL CYCLES IN VERVET MONKEYS (CERCOPITHECUS AETHIOPS)

黑长尾猴（CERCOPITHECUS AETHIOPS）的子宫内膜周期

• 批准号: 7348926
• 负责人: OV D SLAYDEN
• 金额: $ 7.68万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7348926
• 关键词: ENDOMETRIAL; CYCLES; VERVET; MONKEYS; CERCOPITHECUS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Old world nonhuman primates, especially macaques, have long been the experimental animal model of choice for studies of hormone action in the endometrium. Macaques are becoming increasingly difficult to obtain and it is important to assess other primate animal models for studies on the reproductive tract. The African green monkey or Vervet is a menstruating nonhuman primate with menstrual cycles of similar duration to those of women. The potential use of Vervets for studies in reproduction has been explored previously. Those studies revealed that menstruation is very light in this species and that daily testing by vaginal swab is required in order to detect menses. The physiological mechanism underlying the attenuated menstruation in this species has not been previously explored. Therefore, our goal was to assess the cyclic effects of estradiol (E2) and progesterone (P) on the regulation of menstruation this species.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。旧大陆非人灵长类动物，特别是猕猴，长期以来一直是研究子宫内膜激素作用的实验动物模型。猕猴变得越来越难获得，重要的是要评估其他灵长类动物模型的生殖道研究。非洲绿色猴（英语：African green monkey）是一种非人类灵长类动物，其月经周期与女性相似。在生殖研究中的潜在用途的秃鹫以前已经探讨过。这些研究表明，这一物种的月经量很轻，需要每天用阴道拭子进行测试，以检测月经。在这个物种的月经减少的生理机制还没有被探索过。因此，我们的目标是评估雌激素（E2）和孕激素（P）对该物种月经调节的周期效应。