GENE THERAPY FOR BRAIN TUMORS

描述(由申请人提供)： 这份续签申请要求为NENPRC的多学科生物医学研究和资源计划的继续提供五年的资金。研究人员将继续执行美国国立卫生研究院(NIH)指导的使命，利用非人类灵长类动物(NHP)的独特特征进行有价值的研究，有助于了解和解决人类健康疾病。为了推进这一目标，应用的重点是支持七个科学核心(行为生物学、比较病理学、免疫学、微生物学、神经化学、灵长类资源和肿瘤病毒学)；进行试点研究；并提供中心范围的支持服务，重点是传染病的发病机制、艾滋病的治疗和预防、基础免疫学、疱疹病毒的致瘤性、神经退行性疾病和药物成瘾。此外，这项建议旨在：1)通过提供专门的设施、设备和技术专长，增强中心作为区域、国家和国际合作、附属和访问科学家的资源的能力；2)增加NHP的可用性，用于生物医学研究；3)培训年轻的研究人员；以及4)提供维持和运营中心所需的行政、科学和灵长类资源基础设施。四个与群体健康相关的资源项目也包括在本申请中，以及五年改善和现代化计划。NNPRC，HMS，是由美国实验动物护理国际认可协会(AAALAC)完全认可的。

DESCRIPTION (provided by applicant): This renewal application requests five years of funding for the continuation of the NENPRC's multidisciplinary biomedical research and resource program. The investigators will continue to pursue the National Institutes of Health (NIH) directed mission of utilizing the unique characteristics of nonhuman primates (NHPs) to conduct meritorious research that contributes to the understanding and solution of human health diseases. To further this objective, the emphasis of the application is to provide support for seven science cores (Behavioral Biology, Comparative Pathology, Immunology, Microbiology, Neurochemistry, Primate Resources, and Tumor Virology); to conduct pilot research; and provide Center-wide support services with emphasis on the pathogenesis of infectious diseases, treatment and prophylaxis of AIDS, basic immunology, ongenicity of herpesvirus, neurodegenerative diseases, and drug addiction. Additionally, this proposal seeks to: 1) enhance the Center's ability to serve as a regional, national, and international resource for collaborative, affiliate, and visiting scientists by providing specialized facilities, equipment, and technological expertise; 2) enhance the availability of NHPs for use in biomedical research; 3) train young investigators; and 4) provide the administrative, scientific, and primate resources infrastructure necessary to maintain and operate a Center. Four colony health-related resource projects are also included in this application as well as a five year Improvement and Modernization Program. The NENPRC, HMS, is fully accredited by the American Association for the Accreditation of Laboratory Animal Care (AAALAC) International.