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MODULATION OF PD-1 EXPRESSION ON T CELLS IN SIV-INFECTED MACAQUES

MODULATION OF PD-1 EXPRESSION ON T CELLS IN SIV-INFECTED MACAQUES
SIV 感染的猕猴 T 细胞上 PD-1 表达的调节
批准号:
8172859
负责人:
R. PAUL JOHNSON
金额:
$20.24万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-05-01 至 2011-04-30

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中文摘要
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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Experiments conducted over the past year have demonstrated that analysis of the costimulatory molecule CD28 in conjunction with PD-1 provides a more accurate definition of exhausted T cells; exhausted cells are PD-1-positive and CD28negative, while activated but functional T cells are PD-1-positive and CD28positive. A manuscript describing these findings has been published.
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