Construction of a Dual Function Primate Facility: ABSL3 and Transplant Medicine

双功能灵长类动物设施的建设：ABSL3 和移植医学

• 批准号: 7877509
• 负责人: R. PAUL JOHNSON
• 金额: $ 1486.82万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-25 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7877509
• 关键词: Address; Air; Animal Experimentation; Animal Technicians; Animals; Area; Bone Marrow; Censuses; Centers for Disease Control and Prevention (U.S.); Cohort Studies; Communicable Diseases; Development; Donor person; Emerging Communicable Diseases; Equipment; Floor; Funding; Growth; Health Priorities; Housing; Immunocompromised Host; Immunology; Immunotherapy; Infectious Diseases Research; Labor Forces; Maintenance; Microbiology; Morbidity - disease rate; National Center for Research Resources; Neurosciences; Occupations; Operating Rooms; Operative Surgical Procedures; Organ; Positioning Attribute; Primates; Quarantine; Request for Proposals; Research; Research Infrastructure; Research Personnel; Research Priority; Services; Specialist; System; Training; Translational Research; Transplantation; Transplanted tissue; Tuberculosis; United States; United States National Institutes of Health; Universities; Work; design; high risk; interstitial; mortality; multidisciplinary; nonhuman primate; operation; programs; psychobiology; sensorimotor system; square foot; success; transplantation medicine

DESCRIPTION (provided by applicant): The Yerkes National Primate Research Center at Emory University is one of eight national primate centers in the United States. With an average daily census of 3400 nonhuman primates (NHPs), the Center supports multidisciplinary translational research in microbiology and immunology, neuroscience, psychobiology and sensory-motor systems. The Center, adjacent to the Centers for Disease Control and Prevention, has grown to become a vital component of the NIH's National Center for Research Resources and currently supports approximately 150 NIH funded projects. However, continued growth of research programs and funding successes have outstripped the capacity of our existing infrastructure to support the basic and translational research for which the Center is so well recognized. In particular, the lack of sufficient NHP ABSL3 space for work on infectious diseases and the increased need for space-intensive facilities required for work with immunocompromised animals has significantly curtailed the Center's ability to respond to national research priorities. Accordingly, this C06 proposal requests funds for construction of a new dual function 19,800 sq ft building devoted to NHP research in two of the most rapidly growing areas of the Yerkes research portfolio that align with national health priorities - infectious disease and transplant medicine. This new facility will address major unmet needs in tuberculosis and other emerging infectious disease threats, and will further the development of immune therapies to reduce morbidity and mortality associated with bone marrow, organ, and tissue transplants. The first floor of the building will be dedicated to infectious disease research, with an ABSL3 capacity for 108 animals in 4 self-sufficient environmentally contained areas that will permit up to 4 concurrent studies, each with unique high-risk agents without danger of cross contamination. The third floor will be dedicated to the Transplant Medicine Facility, have a capacity for quarantine of 80 NHPs and housing up to 168 NHPs post transplant, will include a suite for profoundly immunocompromised animals, and a dedicated operating room for dual transplant donor/recipient surgeries. All building maintenance functions will be housed in an innovatively designed second floor interstitial space so that service and equipment maintenance functions can be performed without the need to enter either ABSL3 space or specialized space for immunocompromised animals. The air handling systems for the ABSL3 floor and the transplant floor will be entirely separated and isolated from each other to preclude the possibility of cross contamination. Construction of this dual function facility will create jobs for an extensive labor force over the next 2 plus years. Moreover, the operation of this new facility will create new positions for at least 12 skilled FTEs, including 6 research personnel, 1 dedicated building manager, 3 animal caretakers, 1 veterinary technician and 1 ABSL3-trained animal research specialist.

描述(申请人提供)：埃默里大学耶克斯国家灵长类研究中心是美国八个国家灵长类研究中心之一。该中心平均每天对3400名非人灵长类动物进行普查，支持微生物学和免疫学、神经科学、心理生物学和感觉-运动系统的多学科转换研究。该中心毗邻疾病控制和预防中心，已发展成为NIH国家研究资源中心的重要组成部分，目前支持约150个NIH资助的项目。然而，研究项目的持续增长和资金的成功已经超出了我们现有基础设施支持基础研究和翻译研究的能力，而该中心因此而备受认可。特别是，缺乏足够的NHP ABSL3空间用于传染病方面的工作，以及对免疫受损动物工作所需的空间密集型设施的需求增加，大大削弱了该中心响应国家研究优先事项的能力。因此，这份C06提案要求提供资金，用于建造一座新的19,800平方英尺的双功能建筑，专门用于耶克斯研究组合中增长最快的两个领域的NHP研究，这两个领域与国家健康优先事项保持一致-传染病和移植药物。这一新设施将解决结核病和其他新出现的传染病威胁方面尚未得到满足的主要需求，并将进一步开发免疫疗法，以降低与骨髓、器官和组织移植相关的发病率和死亡率。该大楼的一楼将专门用于传染病研究，ABSL3可在4个自给自足的环境封闭区域内容纳108只动物，最多可同时进行4项研究，每项研究都有独特的高风险因素，不会有交叉污染的危险。三楼将专门用于移植医学设施，可隔离80个NHP，移植后可容纳多达168个NHP，将包括一套用于免疫严重受损的动物的套间，以及用于双移植供体/受体手术的专用手术室。所有建筑维护功能都将被安置在设计新颖的二楼间隙空间中，这样就可以执行服务和设备维护功能，而无需进入ABSL3空间或专门为免疫受损动物提供的空间。ABSL3层和移植层的空气处理系统将完全分开并相互隔离，以防止交叉污染的可能性。这一双重功能设施的建设将在未来两年多为广泛的劳动力创造就业机会。此外，这个新设施的运营将为至少12名熟练的全职员工创造新的职位，包括6名研究人员、1名专门的建筑经理、3名动物看护员、1名兽医技术员和1名受过ABSL3培训的动物研究专家。