Construction of a Dual Function Primate Facility: ABSL3 and Transplant Medicine

描述（由申请人提供）：埃默里大学的耶基斯国家灵长类动物研究中心是美国八个国家灵长类动物中心之一。该中心平均每天对3400只非人灵长类动物（NHP）进行普查，支持微生物学和免疫学，神经科学，心理生物学和感觉运动系统的多学科转化研究。该中心毗邻疾病控制和预防中心，已发展成为NIH国家研究资源中心的重要组成部分，目前支持大约150个NIH资助的项目。然而，研究项目和资金成功的持续增长已经超过了我们现有的基础设施的能力，以支持该中心是如此公认的基础和转化研究。特别是，缺乏足够的NHP ABSL 3空间用于传染病的工作，以及对免疫功能低下动物工作所需的空间密集型设施的需求增加，大大削弱了该中心响应国家研究重点的能力。因此，该C 06提案要求资金用于建设一座新的19，800平方英尺的双功能建筑，专门用于Yerkes研究组合中两个增长最快的领域的NHP研究，这些领域与国家卫生优先事项-传染病和移植医学保持一致。这一新设施将解决结核病和其他新出现的传染病威胁的主要未满足的需求，并将进一步发展免疫疗法，以降低与骨髓、器官和组织移植相关的发病率和死亡率。该建筑的一楼将专门用于传染病研究，ABSL 3容量为108只动物，位于4个自给自足的环境控制区域，最多可同时进行4项研究，每项研究都有独特的高风险因子，没有交叉污染的危险。三楼将专门用于移植医学设施，可隔离80名NHP，并在移植后容纳多达168名NHP，将包括一间用于严重免疫功能低下动物的套房，以及一间用于双移植供体/受体手术的专用手术室。所有建筑维护功能将安置在创新设计的二楼间隙空间中，以便在无需进入ABSL 3空间或免疫功能低下动物专用空间的情况下执行服务和设备维护功能。ABSL 3层和移植层的空气处理系统将完全分开并相互隔离，以排除交叉污染的可能性。这一双重功能设施的建设将在未来2年多的时间里为大量劳动力创造就业机会。此外，该新设施的运营将为至少12名熟练的FTE创造新的职位，包括6名研究人员，1名专门的建筑经理，3名动物管理员，1名兽医技术员和1名ABSL 3培训的动物研究专家。

DESCRIPTION (provided by applicant): The Yerkes National Primate Research Center at Emory University is one of eight national primate centers in the United States. With an average daily census of 3400 nonhuman primates (NHPs), the Center supports multidisciplinary translational research in microbiology and immunology, neuroscience, psychobiology and sensory-motor systems. The Center, adjacent to the Centers for Disease Control and Prevention, has grown to become a vital component of the NIH's National Center for Research Resources and currently supports approximately 150 NIH funded projects. However, continued growth of research programs and funding successes have outstripped the capacity of our existing infrastructure to support the basic and translational research for which the Center is so well recognized. In particular, the lack of sufficient NHP ABSL3 space for work on infectious diseases and the increased need for space-intensive facilities required for work with immunocompromised animals has significantly curtailed the Center's ability to respond to national research priorities. Accordingly, this C06 proposal requests funds for construction of a new dual function 19,800 sq ft building devoted to NHP research in two of the most rapidly growing areas of the Yerkes research portfolio that align with national health priorities - infectious disease and transplant medicine. This new facility will address major unmet needs in tuberculosis and other emerging infectious disease threats, and will further the development of immune therapies to reduce morbidity and mortality associated with bone marrow, organ, and tissue transplants. The first floor of the building will be dedicated to infectious disease research, with an ABSL3 capacity for 108 animals in 4 self-sufficient environmentally contained areas that will permit up to 4 concurrent studies, each with unique high-risk agents without danger of cross contamination. The third floor will be dedicated to the Transplant Medicine Facility, have a capacity for quarantine of 80 NHPs and housing up to 168 NHPs post transplant, will include a suite for profoundly immunocompromised animals, and a dedicated operating room for dual transplant donor/recipient surgeries. All building maintenance functions will be housed in an innovatively designed second floor interstitial space so that service and equipment maintenance functions can be performed without the need to enter either ABSL3 space or specialized space for immunocompromised animals. The air handling systems for the ABSL3 floor and the transplant floor will be entirely separated and isolated from each other to preclude the possibility of cross contamination. Construction of this dual function facility will create jobs for an extensive labor force over the next 2 plus years. Moreover, the operation of this new facility will create new positions for at least 12 skilled FTEs, including 6 research personnel, 1 dedicated building manager, 3 animal caretakers, 1 veterinary technician and 1 ABSL3-trained animal research specialist.