HEMATOPOIETIC STEM CELLS IN CARDIOVASCULAR REGENERATIVE MEDICINE

描述(申请者提供)：我们将建立一个中心来促进 南卡罗来纳州心血管疾病研究。我们的Cobre专注于 心血管疾病很重要，因为我们州的公民 比全国其他任何地方都更容易患心血管疾病。为 为此，该州的两所医学院联合起来发展了 南卡罗来纳州科布雷谈心血管疾病。这一点将会有重大意义 在南卡罗来纳州加强联合努力，招聘、培训和保留一名 具有多学科技能和足够的调查人员的数量 基础设施：(1)在基本机制方面进行有效协作 心血管疾病研究，以及(2)在 国家一级的NIH和其他功绩审查资金，以支持 并扩展他们的研究努力。提出的五个科学项目 来自五个不同国家的有才华的新招聘终身教职员工 部门，三个高科技科学核心(转基因，成像， 微阵列/蛋白质组学)由具有可靠跟踪的杰出研究人员指导 其专长领域的记录和行政/指导核心 包括拟建的中心。最重要的主题是心血管 疾病源于最终常见的致病途径：增殖， 重塑、凋亡、转分化和血管生成，其中每一种 是一个或多个项目的焦点。虽然主题重点是 心血管方面，实施的可操作性主题是指导。在各州 它们在国家层面上的研究资金竞争力较弱， 对新研究人员的有效指导是一项研究的基本要素 发展规划。该建议通过以下方式直接满足这一需求：(1)配对 有针对性的调查人员由NIH资助的老牌研究人员 出色的指导跟踪记录以及相关的关键专业知识； (2)开展有组织的活动，以获取和提高技能； 如研讨会、期刊社、静修和特别课程；(3) 确保获得必要的核心资源，并提供足够的科学依据 专业知识和技术支持，以优化其使用；以及(4)实施 定期进度报告和评价计划(检查点) 来自国家的外部咨询委员会的重要援助 公认的科学家。

DESCRIPTION (provided by applicant): We will establish a center to promote the study of cardiovascular diseases in South Carolina. Our COBRE focus on cardiovascular disease is significant because the citizens of our state are more prone to cardiovascular disease than anywhere else in the nation. For this reason, the two medical schools in the state have united to develop the South Carolina COBRE on Cardiovascular Disease. This COME will significantly augment joint efforts in South Carolina to recruit, train and retain a critical mass of investigators with multidisciplinary skills and adequate infrastructure to: (1) collaborate effectively in fundamental mechanistic studies of cardiovascular diseases, and (2) compete successfully at the national level for NIH and other merit-reviewed funding required to support and extend their research endeavors. Five scientific projects proposed by talented, newly recruited tenure-track faculty from five different departments, three high tech scientific cores (transgenics, imaging, microarray/proteomics) directed by outstanding investigators with proven track records in their area of expertise and an administrative/mentoring core comprise the proposed center. The overarching theme is that cardiovascular diseases derive from final common pathogenic pathways: proliferation, remodeling, apoptosis, transdifferentiation and vasculogenesis, each of which is the focus of one or more projects. While the thematic focus is cardiovascular, the operant theme for implementation is mentoring. In states that are less competitive for research funding at the national level, effective mentoring of new investigators is an essential element of a research development plan. This proposal addresses this need directly by: (1) pairing targeted investigators with established NIH-funded researchers who have exceptional mentoring track records as well as relevant critical expertise; (2) developing structured activities for skills acquisition and enhancement, such as seminars, journal clubs, retreats and special courses; (3) guaranteeing access to essential core resources with sufficient scientific expertise and technical support to optimize their use; and (4) implementing a regular schedule (checkpoints) of progress reports and evaluation with critical assistance from an External Advisory Committee of nationally recognized scientists.