COBRE: UVM BIOL PROJ 1: CHLORIDE HOMEOSTASIS IN OLFACTORY NEURONS AGING

COBRE：UVM BIOL 项目 1：嗅觉神经元老化中的氯离子稳态

• 批准号: 7170479
• 负责人: RONA J DELAY
• 金额: $ 9.09万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7170479
• 关键词: biological signal transduction; neurogenetics; neuroregulation; neurosciences

DESCRIPTION (provided by applicant): The goal of this application is to establish a Center of Biomedical Research Excellence (COBRE) in Neuroscience at the University of Vermont (UVM). The specific aims of this proposal are: Specific Aim 1: Establish the research and intellectual infrastructure to support a University-wide Center for Neuroscience Excellence at UVM. Goals of this aim include: 1) to establish a mentoring program to support junior neuroscience faculty; 2) to establish an imaging/physiology core to support the research projects of the junior faculty; 3) to establish a cellular/molecular core to support the research projects of the junior faculty; 4) to establish a University-wide Neuroscience Seminar Series and Annual Neuroscience Retreat; 5) to establish a mechanism of communication between basic scientists and clinicians that facilitates development of translational research and 6) to establish a University-wide mechanism for Neuroscience Graduate Education. Specific Aim 2: Support the research development of a core group of junior faculty who will be future leaders in the Center for Neuroscience Excellence. Faculty to be supported and their project titles are: 1) Dr. Rona Delay, Department of Biology: Chloride homeostasis in olfactory neurons; 2) Dr. William Falls, Department of Psychology:Molecular and genetic analysis of learned fear reduction in mice; 3) Dr. Anthony Morielli, Department of Pharmacology: Kinase and cytoskeletal regulation of potassium channels; 4) Dr. Matthew Rand, Department of Anatomy and Neurobiology: Proteolytic modulation of Notch signaling in neurogenesis and 5) Dr. George Wellman, Department of Pharmacology: Mechanisms of cerebral vasospasm in subarachnoid hemorrhage. UVM has established investigators in three areas of neuroscience: molecular/developmental, cellular/systems and clinical/behavioral neuroscience. Award of this application would provide a mechanism to significantly expand research strength in these existing areas of neuroscience emphasis, to integrate basic with clinical neuroscience, and to promote research collaborations university-wide. A level of excellence in research and training will be fostered that is not possible without external support. Productivity of both junior and senior investigators will be stimulated, and a long term mentoring framework will be created. UVM is a small institution in a rural state with limited resources; an award would substantially expand our research infrastructure and significantly increase faculty competitiveness.

描述（由申请人提供）：本申请的目标是 建立神经科学卓越生物医学研究中心（COBRE） 佛蒙特大学University of Vermont（UVM）这项建议的具体目标是： 具体目标1：建立研究和知识基础设施， 支持UVM的全校神经科学卓越中心。目标 这一目标包括：1）建立一个指导计划， 神经科学系; 2）建立成像/生理学核心，以支持 三是要建立一个以教师为中心的学科体系， 细胞/分子核心，以支持初级研究项目 4）建立一个大学范围内的神经科学研讨会系列， 年度神经科学务虚会; 5）建立沟通机制 在基础科学家和临床医生之间， 6）建立一个全校性的机制， 神经科学研究生教育。 具体目标2：支持初级教育核心小组的研究发展 教师谁将是未来的领导者在卓越的神经科学中心。 支持的教师和他们的项目名称是：1）罗娜延迟博士， 生物系：嗅觉神经元中的氯稳态; 威廉·福尔斯，心理学系：分子和遗传分析 学会了减少小鼠的恐惧; 3）安东尼·莫里埃利博士， 药理学：钾通道的激酶和细胞骨架调节; Matthew兰德，解剖学和神经生物学系：蛋白水解调节 Notch信号在神经发生中的作用，以及5）乔治韦尔曼博士， 药理学：蛛网膜下腔出血时脑血管痉挛的机制。 UVM在神经科学的三个领域建立了研究人员： 分子/发育、细胞/系统和临床/行为 神经科学这项申请的裁决将提供一个机制， 显著扩大神经科学现有领域的研究力量 强调，将基础与临床神经科学相结合，并促进 大学范围内的研究合作。在研究方面的卓越水平 培训工作将得到加强，这是没有外部支持就不可能做到的。 初级和高级调查员的生产力将得到激发，并且 将建立长期的指导框架。UVM是一个小机构， 一个资源有限的农村州;一个奖项将大大扩大我们的 研究基础设施，并大大提高教师的竞争力。