Functional Genome/Proteomic--Pathogen-Host Interactions

描述（由申请人提供）： 这个COBRE利用了俄克拉荷马州近年来处于前沿的少数几个生物医学研究领域之一，即细菌致病机理的基因组规模分析。我们建议建立一个COBRE，以细菌-宿主相互作用的功能基因组/蛋白质组学分析为主题。四名初级调查员在三所主要的州立大学校园内获得资助。我们取得了惊人的成功率。所有这些人随后都获得了同行评审的NIH资金，并轮换了赠款。他们的成功使我们能够资助另外四名研究人员，他们处于完成研究项目的不同阶段。最初的COBRE是作为一个典型的计划项目赠款，但重点是年轻的，发展中的科学家在俄克拉荷马州。从第2年到第5年，我们已经发展了赠款的结构和运作，以跟上原始RFA（RR-00-003）后续迭代的变化。这包括最多三年的资助、毕业程序、导师更有条理的角色、包括4个初级项目和2个为期一年的试点项目。这个应用程序继续与蛋白质组学更直接的重点主题。为了支持这一目标，我们正在建立一个蛋白质组学核心实验室，我们正在招募一名蛋白质组学磁铁研究员。该职位的机构支持包括一个专门的终身职位和一个机构资助的启动包增强。我们还在第2-5年预留了资金，以协助与COBRE和俄克拉荷马州INBRE赠款相关的所有俄克拉荷马州机构进行招聘工作，以吸引与研究主题一致的研究人员。此外，与校园内其他两个COBRE赠款的PI相关联，我们正在建立联合研究务虚会和会议，以提高我们资助的研究人员之间的跨学科研究机会。COBRE由一位由NIH资助的研究人员领导，他与INBRE-PI一起沿着领导一项全州范围的倡议，其中包括俄克拉荷马州三家主要的公共支持研究机构和12家机构的网络，其中包括俄克拉荷马州唯一一所历史上的黑人大学，这是一所本科院校，在全国任何一所大学中拥有最多的美国原住民，俄克拉荷马州唯一的部落学院和其他几所拥有大量来自代表性不足群体的学生的机构。

DESCRIPTION (provided by applicant): This COBRE has exploited one of the few areas of biomedical research where Oklahoma has been in the forefront in recent years, which is the genome-scale analysis of bacterial pathogenesis. We proposed to establish a COBRE, with the thematic focus of Functional Genomic/Proteomic Analysis of Bacterial-Host Interactions. Four junior investigators were funded on the three main state university campuses. We achieved a phenomenal success rate. All these individuals have subsequently received peer-reviewed NIH funding and rotated off the grant. Their successes have allowed us to fund an additional four investigators who in are various stages of completion of their research projects. The original COBRE was structured as a typical Program Project Grant, but focused on young, developing scientists in the state of Oklahoma. From years 2 -5 we have evolved the structure and operation of the grant to keep pace with changes in subsequent iterations of the original RFA (RR-00-003). This included a maximum of three years of funding, graduation procedures, more structured roles for mentors, inclusion 4 junior projects and 2 one-year pilot projects. This application continues the main theme with a more directed focus into proteomics. To support this goal, we are establishing a proteomics core laboratory and we are recruiting a proteomics magnet investigator. Institutional support for this position includes a dedicated tenure-earning position and a institutionally funded start-up package enhancement. We also have reserved funds in years 2-5 to assist all Oklahoma institutions associated with this COBRE and the Oklahoma INBRE grant in recruitment efforts to attract investigators who are consistent with the research theme. Further, in association with the PIs of the two other COBRE grants on campus, we are instituting joint research retreats and meetings to enhance interdisciplinary research opportunities among our funded investigators. The COBRE is headed by an established NIH-funded investigator who leads a state-wide initiative along with the INBRE-PI that includes the three major publicly-supported research institutions in the state of Oklahoma and a network of 12 institutions including Oklahoma's only historically black university, an undergraduate institution with the highest number of native Americans of any college in the nation, Oklahoma's only tribal college and several other institutions with large numbers of students from under-represented groups.