COBRE: OUHSC: CORE ADMINISTRATIVE & STATISTICAL CORE

COBRE：OUHSC：核心管理

• 批准号: 7609726
• 负责人: John J. Iandolo
• 金额: $ 41.15万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7609726
• 关键词: Biological; Biology; Biomedical Research; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Disease; Funding; Gene Expression; Genes; Grant; Host resistance; Institution; Laboratories; Mentors; Microarray Analysis; Organism; Peer Review; Process; Proteomics; Regulation; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Site; Source; System; United States National Institutes of Health; concept; functional genomics; multidisciplinary; pathogen; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of the present COBRE program are to strengthen biomedical research infrastructure through the establishment of a thematic multidisciplinary center and to enhance the ability of investigators to compete independently for peer reviewed support. The administratively reorganized program now includes a comprehensive mentoring system, provides adequate funding for research supports outstanding core laboratories on-site and provides a means to include and integrate new investigators as needed in the process. With respect to strengthening biomedical research, our theme of functional genomic and proteomic analysis of host-pathogen interactions is central to understanding the impact of gene expression on pathogen survival and innate host resistance. Each of the original investigators as well as those presently supported use a combination of high-throughput biology employing gene sequencing and microarray technology to identify and study many genes that were previously unspecified. Now, the regulation of the expression of those genes and their products are ready for more specific analysis using more proteomic approaches. It is our intent in this program to develop the proteomic component of this concept to provide answers to questions regarding the biological mechanism of disease caused by the organisms we study.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目前 COBRE 计划的目标是通过建立专题多学科中心来加强生物医学研究基础设施，并提高研究人员独立竞争同行评审支持的能力。经过行政重组的计划现在包括一个全面的指导系统，为研究提供充足的资金，支持优秀的现场核心实验室，并提供一种根据需要纳入和整合新研究人员的方法。 在加强生物医学研究方面，我们对宿主-病原体相互作用的功能基因组和蛋白质组学分析的主题对于了解基因表达对病原体生存和先天宿主抵抗力的影响至关重要。 每个最初的研究人员以及目前支持的研究人员都使用高通量生物学的组合，采用基因测序和微阵列技术来识别和研究许多以前未指定的基因。 现在，这些基因及其产物的表达调控已准备好使用更多蛋白质组学方法进行更具体的分析。 我们在这个项目中的目的是开发这个概念的蛋白质组成分，为有关我们研究的生物体引起的疾病的生物学机制的问题提供答案。