COBRE: OUHSC: CORE ADMINISTRATIVE & STATISTICAL CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 A.具体目标： 目前Cobre计划的目标是通过建立一个专题多学科中心来加强生物医学研究基础设施，并提高研究人员独立竞争同行评审支持的能力。该计划包括一个全面的指导系统，为研究提供充足的资金，在现场支持优秀的核心实验室，并提供一种手段，在这一过程中根据需要纳入和整合新的调查人员。在加强生物医学研究方面，我们对寄主-病原体相互作用的功能基因组和蛋白质组分析是理解基因表达对病原体生存和固有寄主抗性的影响的核心。每个最初的研究人员以及那些目前得到支持的研究人员都使用高通量生物学的组合，使用基因测序和微阵列技术来识别和研究许多以前未指明的基因。现在，这些基因及其产物的表达调控已经准备好用更多的蛋白质组学方法进行更具体的分析。我们在这个项目中的目的是开发这一概念的蛋白质组部分，以提供关于我们研究的生物体引起疾病的生物学机制的问题的答案。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. a. Specific Aims: The objectives of the present COBRE program are to strengthen biomedical research infrastructure through the establishment of a thematic multidisciplinary center and to enhance the ability of investigators to compete independently for peer reviewed support. The program includes a comprehensive mentoring system, provides adequate funding for research, supports outstanding core laboratories on-site and provides a means to include and integrate new investigators as needed in the process. With respect to strengthening biomedical research, our theme of functional genomic and proteomic analysis of host-pathogen interactions is central to understanding the impact of gene expression on pathogen survival and innate host resistance. Each of the original investigators as well as those presently supported use a combination of high-throughput biology employing gene sequencing and microarray technology to identify and study many genes that were previously unspecified. Now, the regulation of the expression of those genes and their products are ready for more specific analysis using more proteomic approaches. It is our intent in this program to develop the proteomic component of this concept to provide answers to questions regarding the biological mechanism of disease caused by the organisms we study.