COBRE: OUHSC: CORE ADMINISTRATIVE & STATISTICAL CORE

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 a.具体目标： 目前的COBRE计划的目标是通过建立一个主题多学科中心来加强生物医学研究基础设施，并提高研究人员独立竞争同行评审支持的能力。该计划包括一个全面的指导系统，为研究提供足够的资金，支持现场优秀的核心实验室，并提供一种手段，包括和整合新的研究人员在这个过程中需要的。 在加强生物医学研究方面，我们的主题是宿主-病原体相互作用的功能基因组学和蛋白质组学分析，这对于理解基因表达对病原体存活和先天宿主抗性的影响至关重要。 最初的研究者以及目前支持的研究者都使用了高通量生物学的组合，采用基因测序和微阵列技术来识别和研究许多以前未指定的基因。 现在，这些基因及其产物的表达调控已经准备好使用更多的蛋白质组学方法进行更具体的分析。 这是我们在这个计划的目的是发展这个概念的蛋白质组学的组成部分，以提供有关我们研究的生物体引起的疾病的生物学机制的问题的答案。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. a. Specific Aims: The objectives of the present COBRE program are to strengthen biomedical research infrastructure through the establishment of a thematic multidisciplinary center and to enhance the ability of investigators to compete independently for peer reviewed support. The program includes a comprehensive mentoring system, provides adequate funding for research, supports outstanding core laboratories on-site and provides a means to include and integrate new investigators as needed in the process. With respect to strengthening biomedical research, our theme of functional genomic and proteomic analysis of host-pathogen interactions is central to understanding the impact of gene expression on pathogen survival and innate host resistance. Each of the original investigators as well as those presently supported use a combination of high-throughput biology employing gene sequencing and microarray technology to identify and study many genes that were previously unspecified. Now, the regulation of the expression of those genes and their products are ready for more specific analysis using more proteomic approaches. It is our intent in this program to develop the proteomic component of this concept to provide answers to questions regarding the biological mechanism of disease caused by the organisms we study.